PGR - Progesterone receptor - human protein (Function)
 
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PGR »  Progesterone receptor  (PR)
 
Protein also known as:  Nuclear receptor subfamily 3 group C member 3.
Gene name:  PGR
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
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1 432 5
GENE REF ISO

Function

 show evidences
Overview 
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.  
8
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Isoform  B   Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Steroid bindingdefinition[GO:0005496]  
  • IEAUniProtKB KW
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Epithelial cell maturationdefinition[GO:0002070] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • IEPUniProtKB
Ovulation from ovarian follicledefinition[GO:0001542] silver  
  • IEAOrtholog Compara
Progesterone receptor signaling pathwaydefinition[GO:0050847] silver  
  • IEAOrtholog Compara
Regulation of epithelial cell proliferationdefinition[GO:0050678] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Tertiary branching involved in mammary gland duct morphogenesisdefinition[GO:0060748] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Oocyte meiosis  hsa04114+5241  
Progesterone-mediated oocyte maturation  hsa04914+5241  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Progesterone_receptor
GenomeRNAi: 5241
PRO: PR:P06401
Chemistry
GuidetoPHARMACOLOGY: 627