PGR - Progesterone receptor - human protein (Function)
 
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PGR »  Progesterone receptor  (PR)
 
Protein also known as:  Nuclear receptor subfamily 3 group C member 3.
Gene name:  PGR
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
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1 459 5
GENE REF ISO

Function

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Overview 
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • PINC
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
  • HGNC
Isoform  B   Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
Steroid bindingdefinition[GO:0005496]  
1
  • UniProtKB KW
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • Ortholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Epithelial cell maturationdefinition[GO:0002070] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • UniProtKB
Ovulation from ovarian follicledefinition[GO:0001542] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Progesterone receptor signaling pathwaydefinition[GO:0050847] silver  
1
  • Ortholog Compara
Regulation of epithelial cell proliferationdefinition[GO:0050678] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Tertiary branching involved in mammary gland duct morphogenesisdefinition[GO:0060748] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Oocyte meiosis  hsa04114+5241  
Progesterone-mediated oocyte maturation  hsa04914+5241  
According to Reactome, this protein belongs to the following pathways:
Nuclear Receptor transcription pathway  REACT_15525  
Nuclear signaling by ERBB4  REACT_116022  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Progesterone_receptor
GenomeRNAi: 5241
PRO: PR:P06401
Chemistry
GuidetoPHARMACOLOGY: 627