APOA4 - Apolipoprotein A-IV - human protein (Function)
 
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APOA4 »  Apolipoprotein A-IV  (ApoA-IV)
 
Protein also known as:  Apolipoprotein A4.
Gene name:  APOA4
Family name: Apolipoprotein A1/A4/E
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.  
1
  • UniProtKB
GO molecular function 
Antioxidant activitydefinition[GO:0016209]  
1
  • HGNC
Cholesterol bindingdefinition[GO:0015485]  
1
  • RefGenome
Cholesterol transporter activitydefinition[GO:0017127]  
1
  • BHF-UCL
Copper ion bindingdefinition[GO:0005507]  
1
  • HGNC
Lipid bindingdefinition[GO:0008289]  
1
  • BHF-UCL
Lipid transporter activitydefinition[GO:0005319]  
1
  • PINC
Phosphatidylcholine bindingdefinition[GO:0031210]  
2
  • BHF-UCL
Phosphatidylcholine-sterol O-acyltransferase activator activitydefinition[GO:0060228]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
GO biological process 
Cholesterol biosynthetic processdefinition[GO:0006695]  
1
  • RefGenome
Cholesterol effluxdefinition[GO:0033344]  
2
  • BHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • BHF-UCL
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • BHF-UCL
Chylomicron assemblydefinition[GO:0034378]  
1
  • BHF-UCL
Chylomicron remodelingdefinition[GO:0034371]  
1
  • BHF-UCL
High-density lipoprotein particle assemblydefinition[GO:0034380]  
1
  • RefGenome
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • BHF-UCL
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
1
  • HGNC
Innate immune response in mucosadefinition[GO:0002227]  
1
  • BHF-UCL
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • BHF-UCL
Lipid homeostasisdefinition[GO:0055088]  
1
  • BHF-UCL
Lipid transportdefinition[GO:0006869]  
2
  • BHF-UCL
Multicellular organismal lipid catabolic processdefinition[GO:0044240]  
1
  • BHF-UCL
Negative regulation of plasma lipoprotein particle oxidationdefinition[GO:0034445]  
1
  • BHF-UCL
Neuron projection regenerationdefinition[GO:0031102]  
1
  • RefGenome
Phosphatidylcholine metabolic processdefinition[GO:0046470]  
1
  • BHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • BHF-UCL
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • BHF-UCL
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723]  
1
  • BHF-UCL
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006]  
1
  • BHF-UCL
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • BHF-UCL
Protein-lipid complex assemblydefinition[GO:0065005]  
1
  • BHF-UCL
Regulation of cholesterol transportdefinition[GO:0032374]  
1
  • BHF-UCL
Regulation of intestinal cholesterol absorptiondefinition[GO:0030300]  
1
  • RefGenome
Removal of superoxide radicalsdefinition[GO:0019430]  
1
  • HGNC
Response to lipid hydroperoxidedefinition[GO:0006982]  
1
  • HGNC
Response to stilbenoiddefinition[GO:0035634] silver  
1
  • Ortholog Compara
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • BHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • RefGenome
Very-low-density lipoprotein particle remodelingdefinition[GO:0034372]  
1
  • BHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
Amyloids  REACT_75925  
Chylomicron-mediated lipid transport  REACT_6841  
Retinoid metabolism and transport  REACT_24968  
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links