CD2 - T-cell surface antigen CD2 - human protein (Function)
 
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CD2 »  T-cell surface antigen CD2
 
Protein also known as:  T-cell surface antigen T11/Leu-5; CD antigen CD2.
Gene name:  CD2
Entry whose protein(s) existence is based on evidence at protein level
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1 70 1
GENE REF ISO

Function

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Overview 
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Receptor activitydefinition[GO:0004872]  
1
  • NASUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
2
  • TASUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASUniProtKB
Cell-cell adhesiondefinition[GO:0016337]  
1
  • NASUniProtKB
Membrane raft polarizationdefinition[GO:0001766]  
2
  • TASUniProtKB
Natural killer cell activationdefinition[GO:0030101]  
1
  • NASUniProtKB
Positive regulation of myeloid dendritic cell activationdefinition[GO:0030887]  
1
  • NASUniProtKB
Regulation of T cell differentiationdefinition[GO:0045580]  
1
  • NASUniProtKB
T cell activationdefinition[GO:0042110]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+914  
Hematopoietic cell lineage  hsa04640+914  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CD2
GenomeRNAi: 914
PRO: PR:P06729
Chemistry
GuidetoPHARMACOLOGY: 2600