FCER2 - Low affinity immunoglobulin epsilon Fc receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
FCER2 »  Low affinity immunoglobulin epsilon Fc receptor
 
Protein also known as:  C-type lectin domain family 4 member J; CD antigen CD23. Cleaved into:  Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form.
Gene name:  FCER2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 97 1
GENE REF ISO

Function

 show evidences
Overview 
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).  
  • CuratedUniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAInterPro 2 GO
IgE bindingdefinition[GO:0019863]  
  • IEAUniProtKB KW
Integrin bindingdefinition[GO:0005178]  
1
  • TASPINC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Positive regulation of humoral immune response mediated by circulating immunoglobulindefinition[GO:0002925] silver  
  • IEAOrtholog Compara
Positive regulation of killing of cells of other organismdefinition[GO:0051712]  
1
  • IDABHF-UCL
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • IDABHF-UCL
Positive regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051770]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Hematopoietic cell lineage  hsa04640+2208  
According to Reactome, this protein belongs to the following pathway:
NOTCH2 intracellular domain regulates transcription  REACT_163910  
Note 
There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD23
GenomeRNAi: 2208
PRO: PR:P06734