GPI - Glucose-6-phosphate isomerase - human protein (Function)
 
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GPI »  Glucose-6-phosphate isomerase   [ EC 5.3.1.9 ]  (GPI)
 
Protein also known as:  Autocrine motility factor (AMF).
Gene name:  GPI
Family name: GPI
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.  
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  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Intramolecular transferase activitydefinition[GO:0016866] silver  
  • IEAOrtholog Compara
Monosaccharide bindingdefinition[GO:0048029] silver  
  • IEAOrtholog Compara
GO biological process 
Aldehyde catabolic processdefinition[GO:0046185] silver  
  • IEAOrtholog Compara
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Glucose 6-phosphate metabolic processdefinition[GO:0051156] silver  
  • IEAOrtholog Compara
Glycolytic processdefinition[GO:0006096]  
  • IEAUniPathway
Hemostasisdefinition[GO:0007599]  
1
  • TASPINC
Humoral immune responsedefinition[GO:0006959]  
1
  • TASPINC
Learning or memorydefinition[GO:0007611] silver  
  • IEAOrtholog Compara
Methylglyoxal biosynthetic processdefinition[GO:0019242] silver  
  • IEAOrtholog Compara
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.1.9: D-glucose 6-phosphate D-fructose 6-phosphate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+2821  
Glycolysis / Gluconeogenesis  hsa00010+2821  
Metabolic pathways  hsa01100+2821  
Pentose phosphate pathway  hsa00030+2821  
Starch and sucrose metabolism  hsa00500+2821  
According to Reactome, this protein belongs to the following pathways:
Gluconeogenesis  REACT_1520  
Glycolysis  REACT_1383  
 
More information is available from:
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Gluconeogenesis  definition   [KW-0312]
Glycolysis  definition   [KW-0324]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P06744
Other
GeneWiki: Glucose-6-phosphate_isomerase
GenomeRNAi: 2821
PRO: PR:P06744