NPM1 - Nucleophosmin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
NPM1 »  Nucleophosmin  (NPM)
 
Protein also known as:  Nucleolar phosphoprotein B23.
Gene name:  NPM1
Family name: Nucleoplasmin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 381 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.  
8
  • CuratedUniProtKB
GO molecular function 
Histone bindingdefinition[GO:0042393]  
1
  • IDAUniProtKB
NF-kappaB bindingdefinition[GO:0051059]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
24
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IMPUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein kinase inhibitor activitydefinition[GO:0004860]  
1
  • IDAUniProtKB
Ribosomal large subunit bindingdefinition[GO:0043023]  
1
  • IDAMGI
Ribosomal small subunit bindingdefinition[GO:0043024]  
1
  • IDAMGI
RNA bindingdefinition[GO:0003723]  
1
  • IDAUniProtKB
Tat protein bindingdefinition[GO:0030957]  
1
  • IDAUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IDAUniProtKB
Unfolded protein bindingdefinition[GO:0051082]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
GO biological process 
Cell agingdefinition[GO:0007569]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Centrosome cycledefinition[GO:0007098]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
DNA repairdefinition[GO:0006281]  
1
  • IDAUniProtKB
Intracellular protein transportdefinition[GO:0006886]  
1
  • TASUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
2
  • NASUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Negative regulation of centrosome duplicationdefinition[GO:0010826]  
1
  • IMPUniProtKB
Negative regulation of protein kinase activity by regulation of protein phosphorylationdefinition[GO:0044387]  
1
  • IDAUniProtKB
Nucleocytoplasmic transportdefinition[GO:0006913]  
2
  • IDAUniProtKB
Nucleosome assemblydefinition[GO:0006334]  
1
  • IDAUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPUniProtKB
Positive regulation of translationdefinition[GO:0045727]  
1
  • IDAUniProtKB
Protein localizationdefinition[GO:0008104]  
1
  • IDAUniProtKB
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAMGI
Regulation of centriole replicationdefinition[GO:0046599]  
1
  • IMPUniProtKB
Regulation of eIF2 alpha phosphorylation by dsRNAdefinition[GO:0060735]  
1
  • IDAUniProtKB
Regulation of endodeoxyribonuclease activitydefinition[GO:0032071]  
1
  • IDAUniProtKB
Regulation of endoribonuclease activitydefinition[GO:0060699]  
1
  • IDAUniProtKB
Response to stressdefinition[GO:0006950]  
1
  • IMPUniProtKB
Ribosome assemblydefinition[GO:0042255]  
1
  • TASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Disease  REACT_116125  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NPM1
GenomeRNAi: 4869
PRO: PR:P06748