CRH - Corticoliberin - human protein (Function)
 
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CRH »  Corticoliberin
 
Protein also known as:  Corticotropin-releasing hormone.
Gene name:  CRH
Entry whose protein(s) existence is based on evidence at protein level
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1 121 1
GENE REF ISO

Function

 show evidences
Overview 
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.  
  • CuratedUniProtKB
GO molecular function 
Corticotropin-releasing hormone activitydefinition[GO:0017045] silver  
  • IEAOrtholog Compara
Corticotropin-releasing hormone receptor 1 bindingdefinition[GO:0051430] silver  
  • IEAOrtholog Compara
Corticotropin-releasing hormone receptor 2 bindingdefinition[GO:0051431] silver  
  • IEAOrtholog Compara
Hormone activitydefinition[GO:0005179]  
1
  • TASPINC
Neuropeptide hormone activitydefinition[GO:0005184]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
  • IEAOrtholog Compara
Associative learningdefinition[GO:0008306] silver  
  • IEAOrtholog Compara
Cellular response to cocainedefinition[GO:0071314] silver  
  • IEAOrtholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
  • IEAOrtholog Compara
Diterpenoid metabolic processdefinition[GO:0016101] silver  
  • IEAOrtholog Compara
Feeding behaviordefinition[GO:0007631] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565]  
1
  • IDAUniProtKB
Ferulate metabolic processdefinition[GO:0033494] silver  
  • IEAOrtholog Compara
Glucocorticoid biosynthetic processdefinition[GO:0006704] silver  
  • IEAOrtholog Compara
Hormone-mediated apoptotic signaling pathwaydefinition[GO:0008628] silver  
  • IEAOrtholog Compara
Hypothalamus developmentdefinition[GO:0021854] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • IDAUniProtKB
Ion homeostasisdefinition[GO:0050801] silver  
  • IEAOrtholog Compara
Learning or memorydefinition[GO:0007611]  
1
  • TASPINC
Locomotory exploration behaviordefinition[GO:0035641] silver  
  • IEAOrtholog Compara
Long-term memorydefinition[GO:0007616] silver  
  • IEAOrtholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Negative regulation of cell deathdefinition[GO:0060548] silver  
  • IEAOrtholog Compara
Negative regulation of circadian sleep/wake cycle, REM sleepdefinition[GO:0042322]  
1
  • NASBHF-UCL
Negative regulation of epinephrine secretiondefinition[GO:0032811] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
  • IEAOrtholog Compara
Negative regulation of glucagon secretiondefinition[GO:0070093] silver  
  • IEAOrtholog Compara
Negative regulation of luteinizing hormone secretiondefinition[GO:0033685] silver  
  • IEAOrtholog Compara
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
  • IEAOrtholog Compara
Parturitiondefinition[GO:0007567]  
1
  • TASPINC
Positive regulation of behavioral fear responsedefinition[GO:2000987] silver  
  • IEAOrtholog Compara
Positive regulation of calcium ion importdefinition[GO:0090280] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819] silver  
  • IEAOrtholog Compara
Positive regulation of cell deathdefinition[GO:0010942] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of circadian sleep/wake cycle, wakefulnessdefinition[GO:0010841]  
1
  • NASBHF-UCL
Positive regulation of corticosterone secretiondefinition[GO:2000854] silver  
  • IEAOrtholog Compara
Positive regulation of corticotropin secretiondefinition[GO:0051461] silver  
  • IEAOrtholog Compara
Positive regulation of cortisol secretiondefinition[GO:0051464]  
1
  • IDABHF-UCL
Positive regulation of digestive system processdefinition[GO:0060456] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Positive regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0035774] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Regulation of N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:2000310]  
1
  • IDAUniProtKB
Regulation of serotonin secretiondefinition[GO:0014062] silver  
  • IEAOrtholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to etherdefinition[GO:0045472] silver  
  • IEAOrtholog Compara
Response to immobilization stressdefinition[GO:0035902] silver  
  • IEAOrtholog Compara
Response to paindefinition[GO:0048265] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Synaptic transmission, dopaminergicdefinition[GO:0001963]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Long-term depression  hsa04730+1392  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  REACT_18372  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links