CRH - Corticoliberin - human protein (Function)
 
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Protein
Gene
References

 
CRH »  Corticoliberin
 
Protein also known as:  Corticotropin-releasing hormone.
Gene name:  CRH
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).  
3
  • UniProtKB
GO molecular function 
Corticotropin-releasing hormone receptor 1 bindingdefinition[GO:0051430] silver  
1
  • Ortholog Compara
Corticotropin-releasing hormone receptor 2 bindingdefinition[GO:0051431] silver  
1
  • Ortholog Compara
Hormone activitydefinition[GO:0005179]  
1
  • PINC
Neuropeptide hormone activitydefinition[GO:0005184]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • PINC
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
1
  • Ortholog Compara
Associative learningdefinition[GO:0008306] silver  
1
  • Ortholog Compara
Cellular response to cocainedefinition[GO:0071314] silver  
1
  • Ortholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Diterpenoid metabolic processdefinition[GO:0016101] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565]  
1
  • UniProtKB
Glucocorticoid biosynthetic processdefinition[GO:0006704] silver  
1
  • Ortholog Compara
Hormone-mediated apoptotic signaling pathwaydefinition[GO:0008628] silver  
1
  • Ortholog Compara
Hypothalamus developmentdefinition[GO:0021854] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB
Ion homeostasisdefinition[GO:0050801] silver  
1
  • Ortholog Compara
Learning or memorydefinition[GO:0007611]  
1
  • PINC
Locomotory exploration behaviordefinition[GO:0035641] silver  
1
  • Ortholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
1
  • Ortholog Compara
Negative regulation of cell deathdefinition[GO:0060548] silver  
1
  • Ortholog Compara
Negative regulation of circadian sleep/wake cycle, REM sleepdefinition[GO:0042322]  
1
  • BHF-UCL
Negative regulation of epinephrine secretiondefinition[GO:0032811] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
1
  • Ortholog Compara
Negative regulation of glucagon secretiondefinition[GO:0070093] silver  
1
  • Ortholog Compara
Negative regulation of luteinizing hormone secretiondefinition[GO:0033685] silver  
1
  • Ortholog Compara
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
1
  • Ortholog Compara
Parturitiondefinition[GO:0007567]  
1
  • PINC
Positive regulation of behavioral fear responsedefinition[GO:2000987] silver  
1
  • Ortholog Compara
Positive regulation of calcium ion importdefinition[GO:0090280] silver  
1
  • Ortholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819] silver  
1
  • Ortholog Compara
Positive regulation of cell deathdefinition[GO:0010942] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of circadian sleep/wake cycle, wakefulnessdefinition[GO:0010841]  
1
  • BHF-UCL
Positive regulation of corticosterone secretiondefinition[GO:2000854] silver  
1
  • Ortholog Compara
Positive regulation of corticotropin secretiondefinition[GO:0051461] silver  
1
  • Ortholog Compara
Positive regulation of cortisol secretiondefinition[GO:0051464]  
1
  • BHF-UCL
Positive regulation of digestive system processdefinition[GO:0060456] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
1
  • Ortholog Compara
Positive regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0035774] silver  
1
  • Ortholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
1
  • Ortholog Compara
Regulation of N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:2000310]  
1
  • UniProtKB
Regulation of serotonin secretiondefinition[GO:0014062] silver  
1
  • Ortholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to etherdefinition[GO:0045472] silver  
1
  • Ortholog Compara
Response to immobilization stressdefinition[GO:0035902] silver  
1
  • Ortholog Compara
Response to paindefinition[GO:0048265] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Synaptic transmissiondefinition[GO:0007268]  
1
  • PINC
Synaptic transmission, dopaminergicdefinition[GO:0001963]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Long-term depression  hsa04730+1392  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  R-HSA-373080  
G alpha (s) signalling events  R-HSA-418555  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links