LPL - Lipoprotein lipase - human protein (Function)
 
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LPL »  Lipoprotein lipase   [ EC 3.1.1.34 ]  (LPL)
 
Gene name:  LPL
Family name: AB hydrolase » Lipase
Entry whose protein(s) existence is based on evidence at protein level
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1 346 1
GENE REF ISO

Function

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Overview 
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
1
  • IPIBHF-UCL
Heparin bindingdefinition[GO:0008201]  
1
  • IDABHF-UCL
Lipoprotein lipase activitydefinition[GO:0004465]  
2
  • ISSBHF-UCL
Phospholipase activitydefinition[GO:0004620]  
1
  • ISSBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Triglyceride bindingdefinition[GO:0017129] silver  
  • IEAOrtholog Compara
Triglyceride lipase activitydefinition[GO:0004806]  
3
  • IDABHF-UCL
GO biological process 
Chylomicron remodelingdefinition[GO:0034371]  
1
  • ICBHF-UCL
Fatty acid biosynthetic processdefinition[GO:0006633]  
2
  • ICBHF-UCL
  • ISSOrtholog Curator
Phospholipid metabolic processdefinition[GO:0006644]  
1
  • ISSBHF-UCL
Positive regulation of cholesterol storagedefinition[GO:0010886]  
1
  • IMPBHF-UCL
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
1
  • ICBHF-UCL
Positive regulation of sequestering of triglyceridedefinition[GO:0010890]  
1
  • IMPBHF-UCL
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Triglyceride biosynthetic processdefinition[GO:0019432] silver  
  • IEAOrtholog Compara
Triglyceride catabolic processdefinition[GO:0019433]  
2
  • IDABHF-UCL
  • ISSOrtholog Curator
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • IGIBHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
1
  • ISSBHF-UCL
Very-low-density lipoprotein particle remodelingdefinition[GO:0034372]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.34: Triacylglycerol + H(2)O diacylglycerol + a carboxylate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4023  
Glycerolipid metabolism  hsa00561+4023  
PPAR signaling pathway  hsa03320+4023  
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
Retinoid metabolism and transport  REACT_24968  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Lipoprotein_lipase
GenomeRNAi: 4023
PRO: PR:P06858