CALCA - Calcitonin gene-related peptide 1 - human protein (Function)
 
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CALCA »  Calcitonin gene-related peptide 1
 
Protein also known as:  Calcitonin gene-related peptide I (CGRP-I).
Gene name:  CALCA
Family name: Calcitonin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 212 1
GENE REF ISO

Function

 show evidences
Overview 
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the cytotoxic amylin (amylin) family  1.C.49.1.2  
GO molecular function 
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IDAUniProtKB
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
2
  • IDAUniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
1
  • IDAUniProtKB
Endothelial cell migrationdefinition[GO:0043542]  
1
  • IDAUniProtKB
Endothelial cell proliferationdefinition[GO:0001935]  
1
  • IDAUniProtKB
G-protein coupled receptor internalizationdefinition[GO:0002031]  
1
  • IDAUniProtKB
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • IDAUniProtKB
Negative regulation of blood pressuredefinition[GO:0045776]  
1
  • IDAMGI
Negative regulation of bone resorptiondefinition[GO:0045779]  
1
  • IDAUniProtKB
Negative regulation of calcium ion transport into cytosoldefinition[GO:0010523]  
1
  • IDAUniProtKB
Negative regulation of osteoclast differentiationdefinition[GO:0045671]  
1
  • IDAUniProtKB
Neurological system process involved in regulation of systemic arterial blood pressuredefinition[GO:0001976]  
1
  • IDAMGI
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
2
  • IDAUniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
1
  • IDAUniProtKB
Positive regulation of interleukin-1 alpha productiondefinition[GO:0032730]  
1
  • IDAUniProtKB
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • IDAUniProtKB
Positive regulation of macrophage differentiationdefinition[GO:0045651]  
1
  • IDAUniProtKB
Positive regulation of vasodilationdefinition[GO:0045909]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Regulation of blood pressuredefinition[GO:0008217]  
1
  • NASUniProtKB
Vasculature developmentdefinition[GO:0001944]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Calcitonin-like ligand receptors  REACT_18290  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 796
PRO: PR:P06881