SERPINE2 - Glia-derived nexin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SERPINE2 »  Glia-derived nexin  (GDN)
 
Protein also known as:  Peptidase inhibitor 7 (PI-7).
Gene name:  SERPINE2
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 56 3
GENE REF ISO

Function

 show evidences
Overview 
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.  
  • CuratedUniProtKB
GO molecular function 
Glycosaminoglycan bindingdefinition[GO:0005539]  
1
  • IDABHF-UCL
Heparin bindingdefinition[GO:0008201]  
2
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
4
  • IMPBHF-UCL
  • IDAMGI
GO biological process 
Blood coagulationdefinition[GO:0007596] silver  
  • IEAOrtholog Compara
Cerebellar granular layer morphogenesisdefinition[GO:0021683] silver  
  • IEAOrtholog Compara
Detection of mechanical stimulus involved in sensory perceptiondefinition[GO:0050974] silver  
  • IEAOrtholog Compara
Innervationdefinition[GO:0060384] silver  
  • IEAOrtholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
  • IEAOrtholog Compara
Mating plug formationdefinition[GO:0042628] silver  
  • IEAOrtholog Compara
Negative regulation of blood coagulationdefinition[GO:0030195]  
2
  • ICBHF-UCL
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Negative regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014067] silver  
  • IEAOrtholog Compara
Negative regulation of plasminogen activationdefinition[GO:0010757]  
1
  • IMPBHF-UCL
Negative regulation of platelet activationdefinition[GO:0010544] silver  
  • IEAOrtholog Compara
Negative regulation of platelet aggregationdefinition[GO:0090331]  
1
  • ISSBHF-UCL
Negative regulation of protein catabolic processdefinition[GO:0042177] silver  
  • IEAOrtholog Compara
Negative regulation of protein processingdefinition[GO:0010955]  
1
  • ICBHF-UCL
Negative regulation of proteolysisdefinition[GO:0045861]  
2
  • IDABHF-UCL
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
  • IEAOrtholog Compara
Negative regulation of sodium ion transportdefinition[GO:0010766] silver  
  • IEAOrtholog Compara
Positive regulation of astrocyte differentiationdefinition[GO:0048711]  
1
  • IDABHF-UCL
Regulation of cell migrationdefinition[GO:0030334]  
1
  • NASUniProtKB
Regulation of synaptic transmission, glutamatergicdefinition[GO:0051966] silver  
  • IEAOrtholog Compara
Regulation of timing of cell differentiationdefinition[GO:0048505] silver  
  • IEAOrtholog Compara
Secretion by celldefinition[GO:0032940] silver  
  • IEAOrtholog Compara
Secretory granule organizationdefinition[GO:0033363] silver  
  • IEAOrtholog Compara
Seminal vesicle epithelium developmentdefinition[GO:0061108] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SERPINE2
GenomeRNAi: 5270
PRO: PR:P07093