EPHX1 - Epoxide hydrolase 1 - human protein (Function)
 
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Protein
Gene
References

 
EPHX1 »  Epoxide hydrolase 1   [ EC 3.3.2.9 ]
 
Protein also known as:  Microsomal epoxide hydrolase.
Gene name:  EPHX1
Family name: Peptidase S33
Entry whose protein(s) existence is based on evidence at protein level
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1 110 1
GENE REF ISO

Function

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Overview 
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.  
  • CuratedUniProtKB
GO molecular function 
Cis-stilbene-oxide hydrolase activitydefinition[GO:0033961]  
  • IEAEC 2 GO
Epoxide hydrolase activitydefinition[GO:0004301]  
1
  • TASPINC
GO biological process 
Aromatic compound catabolic processdefinition[GO:0019439]  
  • IEAUniProtKB KW
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.3.2.9: Cis-stilbene oxide + H(2)O (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+2052  
Metabolism of xenobiotics by cytochrome P450  hsa00980+2052  
 

Keywords

Biological process 
Aromatic hydrocarbons catabolism  definition   [KW-0058]
Detoxification  definition   [KW-0216]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P07099
Other
GeneWiki: EPHX1
GenomeRNAi: 2052
PRO: PR:P07099