LDHB - L-lactate dehydrogenase B chain - human protein (Function)
 
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LDHB »  L-lactate dehydrogenase B chain   [ EC 1.1.1.27 ]  (LDH-B)
 
Protein also known as:  Renal carcinoma antigen NY-REN-46.
Gene name:  LDHB
Family name: LDH/MDH » LDH
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Kinase bindingdefinition[GO:0019900] silver  
  • IEAOrtholog Compara
L-lactate dehydrogenase activitydefinition[GO:0004459]  
  • IEAEC 2 GO
NAD bindingdefinition[GO:0051287] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular carbohydrate metabolic processdefinition[GO:0044262] silver  
  • IEAInterPro 2 GO
Glycolytic processdefinition[GO:0006096]  
  • IEAUniProtKB KW
Lactate metabolic processdefinition[GO:0006089] silver  
  • IEAOrtholog Compara
NAD metabolic processdefinition[GO:0019674] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.27: (S)-lactate + NAD(+) pyruvate + NADH.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+3945  
Glycolysis / Gluconeogenesis  hsa00010+3945  
Metabolic pathways  hsa01100+3945  
Propanoate metabolism  hsa00640+3945  
Pyruvate metabolism  hsa00620+3945  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P07195
Other
GenomeRNAi: 3945
PRO: PR:P07195