PROS1 - Vitamin K-dependent protein S - human protein (Function)
 
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PROS1 »  Vitamin K-dependent protein S
 
Gene name:  PROS1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Endopeptidase inhibitor activitydefinition[GO:0004866]  
1
  • TASPINC
GO biological process 
Fibrinolysisdefinition[GO:0042730]  
  • IEAUniProtKB KW
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+5627  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Immune System  REACT_6900  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Fibrinolysis  definition   [KW-0280]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Protein_S
GenomeRNAi: 5627
PRO: PR:P07225