KLK3 - Prostate-specific antigen - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
KLK3 »  Prostate-specific antigen   [ EC 3.4.21.77 ]  (PSA)
 
Protein also known as:  Gamma-seminoprotein (Seminin).
Gene name:  KLK3
Family name: Peptidase S1 » Kallikrein
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 5
GENE REF ISO

Function

 show evidences
Overview 
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASPINC
GO biological process 
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.77: Preferential cleavage: -Tyr-|-Xaa-.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pathways in cancer  hsa05200+354  
Prostate cancer  hsa05215+354  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Prostate-specific_antigen
GenomeRNAi: 354
PRO: PR:P07288