ASGR1 - Asialoglycoprotein receptor 1 - human protein (Function)
 
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Protein
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References

 
ASGR1 »  Asialoglycoprotein receptor 1  (ASGPR 1)
 
Protein also known as:  C-type lectin domain family 4 member H1.
Gene name:  ASGR1
Entry whose protein(s) existence is based on evidence at protein level
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1 31 2
GENE REF ISO

Function

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Overview 
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.  
  • CuratedUniProtKB
GO molecular function 
Asialoglycoprotein receptor activitydefinition[GO:0004873] silver  
  • IEAOrtholog Compara
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
  • IEAOrtholog Compara
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • TASPINC
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 432
PRO: PR:P07306