FES - Tyrosine-protein kinase Fes/Fps - human protein (Function)
 
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FES »  Tyrosine-protein kinase Fes/Fps   [ EC 2.7.10.2 ]
 
Protein also known as:  Feline sarcoma/Fujinami avian sarcoma oncogene homolog.
Gene name:  FES
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.  
13
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Immunoglobulin receptor bindingdefinition[GO:0034987]  
1
  • IDAUniProtKB
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • IDAUniProtKB
Phosphatidylinositol bindingdefinition[GO:0035091]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • IDAUniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAUniProtKB
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
1
  • IMPUniProtKB
Positive regulation of microtubule polymerizationdefinition[GO:0031116]  
1
  • IMPUniProtKB
Positive regulation of myeloid cell differentiationdefinition[GO:0045639]  
1
  • IMPUniProtKB
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • IMPUniProtKB
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • IMPUniProtKB
Regulation of cell motilitydefinition[GO:2000145]  
1
  • IMPUniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • IMPUniProtKB
Regulation of cell shapedefinition[GO:0008360]  
2
  • IMPUniProtKB
Regulation of mast cell degranulationdefinition[GO:0043304]  
1
  • IMPUniProtKB
Regulation of vesicle-mediated transportdefinition[GO:0060627]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
6
  • CuratedUniProtKB
It is regulated in the following manner
Kinase activity is tightly regulated. Activated in response to signaling from a cell surface receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at Tyr-713. Present in an inactive form in the absence of activating stimuli.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2242  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
Note 
Cellular homolog of retroviral oncogenes. In contrast to the viral oncoproteins, the kinase activity of cellular FSP/FES is tightly regulated, and the kinase is inactive in normal cells in the absence of activating stimuli (PubMed15485904).  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Feline_sarcoma_oncogene
GenomeRNAi: 2242
PRO: PR:P07332
Chemistry
GuidetoPHARMACOLOGY: 2023