CTSD - Cathepsin D - human protein (Function)
 
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CTSD »  Cathepsin D   [ EC 3.4.23.5 ]
 
Cleaved into:  Cathepsin D heavy chain; Cathepsin D light chain.
Gene name:  CTSD
Family name: Peptidase A1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.  
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  • UniProtKB
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
Autophagydefinition[GO:0006914]  
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  • RefGenome
Protein catabolic processdefinition[GO:0030163]  
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  • RefGenome
Proteolysisdefinition[GO:0006508]  
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  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.23.5: Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.  
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  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+1509  
Tuberculosis  hsa05152+1509  
According to Reactome, this protein belongs to the following pathways:
Collagen degradation  R-HSA-1442490  
Metabolism of Angiotensinogen to Angiotensins  R-HSA-2022377  
MHC class II antigen presentation  R-HSA-2132295  
 
More information is available from:
 

Keywords

Molecular function 
Aspartyl protease  definition   [KW-0064]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cathepsin_D
GenomeRNAi: 1509
PRO: PR:P07339
Chemistry
GuidetoPHARMACOLOGY: 2345