ANXA2 - Annexin A2 - human protein (Function)
 
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Gene
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ANXA2 »  Annexin A2
 
Protein also known as:  Placental anticoagulant protein IV (PAP-IV).
Gene name:  ANXA2
Family name: Annexin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the annexin (annexin) family  1.A.31.1.4  
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Calcium-dependent phospholipid bindingdefinition[GO:0005544]  
1
  • UniProtKB
Calcium-dependent protein bindingdefinition[GO:0048306]  
1
  • AgBase
Cytoskeletal protein bindingdefinition[GO:0008092] silver  
1
  • InterPro 2 GO
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
1
  • UniProtKB
Phospholipase A2 inhibitor activitydefinition[GO:0019834]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • BHF-UCL
  • UniProtKB
Rab GTPase bindingdefinition[GO:0017137] silver  
1
  • Ortholog Compara
Contributes to receptor activator activitydefinition[GO:0030546]  
1
  • BHF-UCL
S100 protein bindingdefinition[GO:0044548]  
2
  • UniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB
Body fluid secretiondefinition[GO:0007589] silver  
1
  • Ortholog Compara
Collagen fibril organizationdefinition[GO:0030199] silver  
1
  • Ortholog Compara
Fibrinolysisdefinition[GO:0042730] silver  
1
  • Ortholog Compara
Membrane buddingdefinition[GO:0006900]  
1
  • UniProtKB
Membrane raft assemblydefinition[GO:0001765]  
1
  • UniProtKB
Negative regulation of catalytic activitydefinition[GO:0043086]  
2
  • GOC
  • InterPro 2 GO
Negative regulation of low-density lipoprotein particle receptor catabolic processdefinition[GO:0032804]  
1
  • BHF-UCL
Negative regulation of receptor bindingdefinition[GO:1900121]  
1
  • BHF-UCL
Negative regulation of receptor internalizationdefinition[GO:0002091]  
1
  • BHF-UCL
Osteoclast developmentdefinition[GO:0036035]  
1
  • UniProtKB
Positive regulation of bindingdefinition[GO:0051099] silver  
1
  • Ortholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
1
  • Ortholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
1
  • Ortholog Compara
Positive regulation of receptor activitydefinition[GO:2000273]  
1
  • BHF-UCL
Positive regulation of vesicle fusiondefinition[GO:0031340]  
1
  • UniProtKB
Protein heterotetramerizationdefinition[GO:0051290]  
2
  • UniProtKB
Protein targeting to plasma membranedefinition[GO:0072661] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Dissolution of Fibrin Clot  REACT_641  
Orphan transporters  REACT_268444  
Note 
It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Annexin_A2
GenomeRNAi: 302
PRO: PR:P07355