C8A - Complement component C8 alpha chain - human protein (Function)
 
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C8A »  Complement component C8 alpha chain
 
Protein also known as:  Complement component 8 subunit alpha.
Gene name:  C8A
Family name: Complement C6/C7/C8/C9
Entry whose protein(s) existence is based on evidence at protein level
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1 41 1
GENE REF ISO

Function

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Overview 
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the membrane attack complex/perforin (macpf) family  1.C.39.3.1  
GO molecular function 
Complement bindingdefinition[GO:0001848] silver  
  • IEAOrtholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
GO biological process 
Complement activationdefinition[GO:0006956]  
1
  • IDAMGI
Complement activation, alternative pathwaydefinition[GO:0006957]  
  • IEAUniProtKB KW
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Cytolysisdefinition[GO:0019835] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+731  
Complement and coagulation cascades  hsa04610+731  
Prion diseases  hsa05020+731  
Systemic lupus erythematosus  hsa05322+731  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Complement alternate pathway  definition   [KW-0179]
Complement pathway  definition   [KW-0180]
Cytolysis  definition   [KW-0204]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 731
PRO: PR:P07357