CAPN1 - Calpain-1 catalytic subunit - human protein (Function)
 
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CAPN1 »  Calpain-1 catalytic subunit   [ EC 3.4.22.52 ]
 
Protein also known as:  Cell proliferation-inducing gene 30 protein.
Gene name:  CAPN1
Family name: Peptidase C2
Entry whose protein(s) existence is based on evidence at protein level
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1 117 1
GENE REF ISO

Function

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Overview 
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Calcium-dependent cysteine-type endopeptidase activitydefinition[GO:0004198]  
  • ISSOrtholog Curator
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
GO biological process 
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Proteolysisdefinition[GO:0006508]  
  • ISSOrtholog Curator
  • IBARefGenome
Receptor catabolic processdefinition[GO:0032801] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.52: Broad endopeptidase specificity.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 4 calcium ions.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by micromolar concentrations of calcium and inhibited by calpastatin.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+823  
Apoptosis  hsa04210+823  
Protein processing in endoplasmic reticulum  hsa04141+823  
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CAPN1
GenomeRNAi: 823
PRO: PR:P07384