TUBB - Tubulin beta chain - human protein (Function)
 
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TUBB »  Tubulin beta chain
 
Protein also known as:  Tubulin beta-5 chain.
Gene name:  TUBB
Family name: Tubulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.  
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activating protein bindingdefinition[GO:0032794] silver  
  • IEAOrtholog Compara
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
MHC class I protein bindingdefinition[GO:0042288]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
  • IEAOrtholog Compara
Structural molecule activitydefinition[GO:0005198]  
1
  • TASBHF-UCL
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • TASBHF-UCL
Cellular component movementdefinition[GO:0006928]  
1
  • TASUniProtKB
Cellular processdefinition[GO:0009987]  
1
  • IDADFLAT
Cytoskeleton-dependent intracellular transportdefinition[GO:0030705]  
1
  • TASBHF-UCL
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAInterPro 2 GO
Microtubule-based processdefinition[GO:0007017]  
1
  • TASBHF-UCL
Natural killer cell mediated cytotoxicitydefinition[GO:0042267]  
1
  • NASUniProtKB
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAInterPro 2 GO
Spindle assemblydefinition[GO:0051225] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+203068  
Pathogenic Escherichia coli infection  hsa05130+203068  
Phagosome  hsa04145+203068  
According to Reactome, this protein belongs to the following pathways:
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TUBB
GenomeRNAi: 203068
PRO: PR:P07437
Chemistry
GuidetoPHARMACOLOGY: 2640