CA3 - Carbonic anhydrase 3 - human protein (Function)
 
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Protein
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CA3 »  Carbonic anhydrase 3   [ EC 4.2.1.1 ]
 
Protein also known as:  Carbonate dehydratase III.
Gene name:  CA3
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

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Overview 
Reversible hydration of carbon dioxide.  
  • CuratedUniProtKB
GO molecular function 
Carbonate dehydratase activitydefinition[GO:0004089]  
  • IEAEC 2 GO
Nickel cation bindingdefinition[GO:0016151] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
One-carbon metabolic processdefinition[GO:0006730] silver  
  • IEAInterPro 2 GO
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.1: H(2)CO(3) CO(2) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by proton donors such as imidazole and the dipeptide histidylhistidine. Inhibited by coumarins and sulfonamide derivatives such as acetazolamide.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Nitrogen metabolism  hsa00910+761  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 52.0 mM for CO(2)

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links