PRSS1 - Trypsin-1 - human protein (Function)
 
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PRSS1 »  Trypsin-1   [ EC 3.4.21.4 ]
 
Protein also known as:  Cationic trypsinogen. Cleaved into:  Alpha-trypsin chain 1; Alpha-trypsin chain 2.
Gene name:  PRSS1
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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1 89 1
GENE REF ISO

Function

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Overview 
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • TASUniProtKB
GO biological process 
Digestiondefinition[GO:0007586]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.4: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Influenza A  hsa05164+5644  
Neuroactive ligand-receptor interaction  hsa04080+5644  
Pancreatic secretion  hsa04972+5644  
Protein digestion and absorption  hsa04974+5644  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Extracellular matrix organization  REACT_118779  
Metabolism  REACT_111217  
Caution 
Tyr-154 was proposed to be phosphorylated (PubMed8683601) but it has been shown (PubMed17087724) to be sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous interpretation of the results.  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Digestion  definition   [KW-0222]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Trypsin_1
GenomeRNAi: 5644
PRO: PR:P07477
Chemistry
GuidetoPHARMACOLOGY: 2397