CHRNG - Acetylcholine receptor subunit gamma - human protein (Function)
 
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Protein
Gene
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CHRNG »  Acetylcholine receptor subunit gamma
 
Gene name:  CHRNG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.1  
GO molecular function 
Contributes to acetylcholine bindingdefinition[GO:0042166]  
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  • RefGenome
Acetylcholine receptor activitydefinition[GO:0015464]  
1
  • PINC
Contributes to acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
1
  • RefGenome
Channel activitydefinition[GO:0015267]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Cation transmembrane transportdefinition[GO:0098655]  
1
  • RefGenome
Muscle contractiondefinition[GO:0006936]  
1
  • PINC
Neurological system processdefinition[GO:0050877]  
1
  • RefGenome
Neuromuscular synaptic transmissiondefinition[GO:0007274]  
1
  • RefGenome
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • RefGenome
Response to nicotinedefinition[GO:0035094]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Synaptic transmission, cholinergicdefinition[GO:0007271]  
1
  • RefGenome
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1146  
According to Reactome, this protein belongs to the following pathway:
Highly sodium permeable acetylcholine nicotinic receptors  R-HSA-629587  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNG
GenomeRNAi: 1146
PRO: PR:P07510
Chemistry
GuidetoPHARMACOLOGY: 475