ADRB2 - Beta-2 adrenergic receptor - human protein (Function)
 
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ADRB2 »  Beta-2 adrenergic receptor
 
Protein also known as:  Beta-2 adrenoreceptor (Beta-2 adrenoceptor).
Gene name:  ADRB2
Entry whose protein(s) existence is based on evidence at protein level
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1 499 1
GENE REF ISO

Function

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Overview 
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.3.5  
GO molecular function 
Adenylate cyclase bindingdefinition[GO:0008179] silver  
1
  • Ortholog Compara
B2 bradykinin receptor bindingdefinition[GO:0031713] silver  
1
  • Ortholog Compara
Beta2-adrenergic receptor activitydefinition[GO:0004941]  
1
  • HGNC
Dopamine bindingdefinition[GO:0035240] silver  
1
  • Ortholog Compara
Drug bindingdefinition[GO:0008144] silver  
1
  • Ortholog Compara
Epinephrine bindingdefinition[GO:0051379]  
1
  • RefGenome
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
1
  • Ortholog Compara
Ionotropic glutamate receptor bindingdefinition[GO:0035255] silver  
1
  • Ortholog Compara
Norepinephrine bindingdefinition[GO:0051380]  
1
  • HGNC
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
9
  • UniProtKB
  • IntAct
  • HGNC
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • HGNC
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • HGNC
Activation of transmembrane receptor protein tyrosine kinase activitydefinition[GO:0007171]  
1
  • PINC
Adenylate cyclase-activating adrenergic receptor signaling pathwaydefinition[GO:0071880]  
1
  • RefGenome
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • PINC
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Associative learningdefinition[GO:0008306] silver  
1
  • Ortholog Compara
Bone resorptiondefinition[GO:0045453] silver  
1
  • Ortholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • RefGenome
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Desensitization of G-protein coupled receptor protein signaling pathway by arrestindefinition[GO:0002032]  
1
  • HGNC
Diaphragm contractiondefinition[GO:0002086] silver  
1
  • Ortholog Compara
Diet induced thermogenesisdefinition[GO:0002024] silver  
1
  • Ortholog Compara
Endosome to lysosome transportdefinition[GO:0008333]  
1
  • PINC
Estrous cycledefinition[GO:0044849] silver  
1
  • Ortholog Compara
Excitatory postsynaptic potentialdefinition[GO:0060079] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Heat generationdefinition[GO:0031649] silver  
1
  • Ortholog Compara
Liver regenerationdefinition[GO:0097421] silver  
1
  • Ortholog Compara
Mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
1
  • ParkinsonsUK-UCL
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
1
  • Ortholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
1
  • Ortholog Compara
Negative regulation of multicellular organism growthdefinition[GO:0040015] silver  
1
  • Ortholog Compara
Negative regulation of ossificationdefinition[GO:0030279] silver  
1
  • Ortholog Compara
Negative regulation of platelet aggregationdefinition[GO:0090331] silver  
1
  • Ortholog Compara
Negative regulation of smooth muscle contractiondefinition[GO:0045986]  
1
  • RefGenome
Negative regulation of urine volumedefinition[GO:0035811] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of ATPase activitydefinition[GO:0032781] silver  
1
  • Ortholog Compara
Positive regulation of autophagosome maturationdefinition[GO:1901098]  
1
  • GO_central
Positive regulation of bone mineralizationdefinition[GO:0030501] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of lipophagydefinition[GO:1904504]  
1
  • GO_central
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • HGNC
Positive regulation of potassium ion transportdefinition[GO:0043268] silver  
1
  • Ortholog Compara
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • BHF-UCL
Positive regulation of skeletal muscle tissue growthdefinition[GO:0048633] silver  
1
  • Ortholog Compara
Positive regulation of sodium ion transportdefinition[GO:0010765] silver  
1
  • Ortholog Compara
Positive regulation of the force of heart contraction by epinephrinedefinition[GO:0003059] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of vasodilationdefinition[GO:0045909] silver  
1
  • Ortholog Compara
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • HGNC
Regulation of calcium ion transportdefinition[GO:0051924] silver  
1
  • Ortholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
1
  • Ortholog Compara
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Response to dexamethasonedefinition[GO:0071548] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to monoaminedefinition[GO:0071867] silver  
1
  • Ortholog Compara
Response to progesteronedefinition[GO:0032570] silver  
1
  • Ortholog Compara
Response to testosteronedefinition[GO:0033574] silver  
1
  • Ortholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
1
  • Ortholog Compara
Vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressuredefinition[GO:0002025]  
1
  • RefGenome
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+154  
Endocytosis  hsa04144+154  
Neuroactive ligand-receptor interaction  hsa04080+154  
Salivary secretion  hsa04970+154  
According to Reactome, this protein belongs to the following pathways:
Adrenoceptors  R-HSA-390696  
G alpha (s) signalling events  R-HSA-418555  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta-2_adrenergic_receptor
GenomeRNAi: 154
PRO: PR:P07550
Chemistry
GuidetoPHARMACOLOGY: 29