ADRB2 - Beta-2 adrenergic receptor - human protein (Function)
 
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ADRB2 »  Beta-2 adrenergic receptor
 
Protein also known as:  Beta-2 adrenoreceptor (Beta-2 adrenoceptor).
Gene name:  ADRB2
Entry whose protein(s) existence is based on evidence at protein level
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1 422 1
GENE REF ISO

Function

 show evidences
Overview 
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.3.5  
GO molecular function 
Adenylate cyclase bindingdefinition[GO:0008179] silver  
  • IEAOrtholog Compara
Beta2-adrenergic receptor activitydefinition[GO:0004941]  
1
  • IDAHGNC
Norepinephrine bindingdefinition[GO:0051380]  
1
  • IDAHGNC
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
8
  • IPIUniProtKB
  • IPIIntAct
  • IPIHGNC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAHGNC
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • IDAHGNC
Activation of transmembrane receptor protein tyrosine kinase activitydefinition[GO:0007171]  
1
  • TASPINC
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Adrenergic receptor signaling pathwaydefinition[GO:0071875]  
1
  • IDAGOC
Bone resorptiondefinition[GO:0045453] silver  
  • IEAOrtholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Desensitization of G-protein coupled receptor protein signaling pathway by arrestindefinition[GO:0002032]  
1
  • IDAHGNC
Diet induced thermogenesisdefinition[GO:0002024] silver  
  • IEAOrtholog Compara
Endosome to lysosome transportdefinition[GO:0008333]  
1
  • TASPINC
Heat generationdefinition[GO:0031649] silver  
  • IEAOrtholog Compara
Negative regulation of multicellular organism growthdefinition[GO:0040015] silver  
  • IEAOrtholog Compara
Negative regulation of smooth muscle contractiondefinition[GO:0045986] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDAHGNC
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IDAHGNC
Regulation of sodium ion transportdefinition[GO:0002028] silver  
  • IEAOrtholog Compara
Regulation of vasodilationdefinition[GO:0042312] silver  
  • IEAInterPro 2 GO
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressuredefinition[GO:0002025] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+154  
Endocytosis  hsa04144+154  
Neuroactive ligand-receptor interaction  hsa04080+154  
Salivary secretion  hsa04970+154  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta-2_adrenergic_receptor
GenomeRNAi: 154
PRO: PR:P07550
Chemistry
GuidetoPHARMACOLOGY: 29