CTSL - Cathepsin L1 - human protein (Function)
 
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CTSL »  Cathepsin L1   [ EC 3.4.22.15 ]
 
Protein also known as:  Major excreted protein (MEP). Cleaved into:  Cathepsin L1 heavy chain; Cathepsin L1 light chain.
Gene name:  CTSL
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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1 147 1
GENE REF ISO

Function

 show evidences
Overview 
Important for the overall degradation of proteins in lysosomes.  
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • IDABHF-UCL
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • IDAUniProtKB
Fibronectin bindingdefinition[GO:0001968]  
1
  • IPIBHF-UCL
Histone bindingdefinition[GO:0042393]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Proteoglycan bindingdefinition[GO:0043394]  
1
  • IPIBHF-UCL
GO biological process 
Adaptive immune responsedefinition[GO:0002250]  
1
  • IEPUniProtKB
Antigen processing and presentationdefinition[GO:0019882]  
1
  • TASUniProtKB
Cellular response to thyroid hormone stimulusdefinition[GO:0097067]  
1
  • IEPUniProtKB
Collagen catabolic processdefinition[GO:0030574]  
1
  • IDABHF-UCL
Macrophage apoptotic processdefinition[GO:0071888]  
1
  • NASBHF-UCL
Proteolysisdefinition[GO:0006508]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.15: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+1514  
Lysosome  hsa04142+1514  
Phagosome  hsa04145+1514  
Rheumatoid arthritis  hsa05323+1514  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Immune System  REACT_6900  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cathepsin_L1
GenomeRNAi: 1514
PRO: PR:P07711
Chemistry
GuidetoPHARMACOLOGY: 2351