PFN1 - Profilin-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
PFN1 »  Profilin-1
 
Protein also known as:  Epididymis tissue protein Li 184a.
Gene name:  PFN1
Family name: Profilin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 116 1
GENE REF ISO

Function

 show evidences
Overview 
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.  
2
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
2
  • UniProtKB
Actin monomer bindingdefinition[GO:0003785]  
1
  • UniProtKB
Adenyl-nucleotide exchange factor activitydefinition[GO:0000774]  
1
  • UniProtKB
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Proline-rich region bindingdefinition[GO:0070064]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • UniProtKB
  • IntAct
Rho GTPase bindingdefinition[GO:0017048] silver  
1
  • Ortholog Compara
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • InterPro 2 GO
Negative regulation of actin filament bundle assemblydefinition[GO:0032232]  
1
  • UniProtKB
Negative regulation of actin filament polymerizationdefinition[GO:0030837]  
1
  • UniProtKB
Negative regulation of stress fiber assemblydefinition[GO:0051497]  
1
  • UniProtKB
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Positive regulation of actin filament bundle assemblydefinition[GO:0032233]  
1
  • RefGenome
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • UniProtKB
Positive regulation of ATPase activitydefinition[GO:0032781]  
1
  • UniProtKB
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • UniProtKB
Positive regulation of ruffle assemblydefinition[GO:1900029]  
1
  • UniProtKB
Protein stabilizationdefinition[GO:0050821]  
1
  • UniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Regulation of actin cytoskeleton  hsa04810+5216  
Salmonella infection  hsa05132+5216  
Shigellosis  hsa05131+5216  
According to Reactome, this protein belongs to the following pathways:
PCP/CE pathway  R-HSA-4086400  
Platelet degranulation  R-HSA-114608  
RHO GTPases Activate Formins  R-HSA-5663220  
Signaling by Robo receptor  R-HSA-376176  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Profilin_1
GenomeRNAi: 5216
PRO: PR:P07737