PFN1 - Profilin-1 - human protein (Function)
 
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PFN1 »  Profilin-1
 
Protein also known as:  Epididymis tissue protein Li 184a.
Gene name:  PFN1
Family name: Profilin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
2
  • IPIUniProtKB
Adenyl-nucleotide exchange factor activitydefinition[GO:0000774]  
1
  • IDAUniProtKB
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Proline-rich region bindingdefinition[GO:0070064]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
Rho GTPase bindingdefinition[GO:0017048] silver  
  • IEAOrtholog Compara
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAInterPro 2 GO
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
Negative regulation of actin filament bundle assemblydefinition[GO:0032232]  
1
  • IMPUniProtKB
Negative regulation of actin filament polymerizationdefinition[GO:0030837]  
1
  • IDAUniProtKB
Negative regulation of stress fiber assemblydefinition[GO:0051497]  
1
  • IMPUniProtKB
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • IGIUniProtKB
Positive regulation of ATPase activitydefinition[GO:0032781]  
1
  • IDAUniProtKB
Positive regulation of DNA metabolic processdefinition[GO:0051054] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • IMPUniProtKB
Positive regulation of ruffle assemblydefinition[GO:1900029]  
1
  • IMPUniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of viral transcriptiondefinition[GO:0050434] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Regulation of actin cytoskeleton  hsa04810+5216  
Salmonella infection  hsa05132+5216  
Shigellosis  hsa05131+5216  
According to Reactome, this protein belongs to the following pathways:
PCP/CE pathway  REACT_172581  
Signaling by Robo receptor  REACT_19351  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Profilin_1
GenomeRNAi: 5216
PRO: PR:P07737