BPGM - Bisphosphoglycerate mutase - human protein (Function)
 
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BPGM »  Bisphosphoglycerate mutase   [ EC 5.4.2.4 ]  (BPGM)
 
Protein also known as:  2,3-bisphosphoglycerate mutase, erythrocyte.
Gene name:  BPGM
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.  
  • CuratedUniProtKB
GO molecular function 
Bisphosphoglycerate 2-phosphatase activitydefinition[GO:0004083]  
  • IEAEC 2 GO
Bisphosphoglycerate mutase activitydefinition[GO:0004082]  
  • IEAEC 2 GO
Phosphoglycerate mutase activitydefinition[GO:0004619] silver  
  • IEAInterPro 2 GO
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • NASPINC
Dephosphorylationdefinition[GO:0016311]  
  • IEAEC 2 GO
Erythrocyte developmentdefinition[GO:0048821] silver  
  • IEAOrtholog Compara
Glycolytic processdefinition[GO:0006096]  
  • IEAUniProtKB KW
Respiratory gaseous exchangedefinition[GO:0007585]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 5.4.2.4: 3-phospho-D-glyceroyl phosphate 2,3-bisphospho-D-glycerate.  
  • CuratedUniProtKB
EC 5.4.2.11: 2-phospho-D-glycerate 3-phospho-D-glycerate.  
  • CuratedUniProtKB
EC 3.1.3.13: 2,3-bisphospho-D-glycerate + H(2)O 3-phospho-D-glycerate + phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
At alkaline pH BPGM favors the synthase reaction; however, at lower pH the phosphatase reaction is dominant. Inhibited by citrate.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycolysis / Gluconeogenesis  hsa00010+669  
Metabolic pathways  hsa01100+669  
 
More information is available from:
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Hydrolase  definition   [KW-0378]
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P07738
Other
GenomeRNAi: 669
PRO: PR:P07738