APRT - Adenine phosphoribosyltransferase - human protein (Function)
 
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Protein
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References

 
APRT »  Adenine phosphoribosyltransferase   [ EC 2.4.2.7 ]  (APRT)
 
Gene name:  APRT
Entry whose protein(s) existence is based on evidence at protein level
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1 38 2
GENE REF ISO

Function

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Overview 
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.  
  • CuratedUniProtKB
GO molecular function 
Adenine bindingdefinition[GO:0002055] silver  
  • IEAOrtholog Compara
AMP bindingdefinition[GO:0016208]  
1
  • IDAMGI
GO biological process 
Adenine salvagedefinition[GO:0006168] silver  
  • IEAOrtholog Compara
AMP salvagedefinition[GO:0044209]  
  • IEAUniPathway
Cellular response to insulin stimulusdefinition[GO:0032869] silver  
  • IEAOrtholog Compara
Grooming behaviordefinition[GO:0007625] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Purine ribonucleoside salvagedefinition[GO:0006166] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.2.7: AMP + diphosphate adenine + 5-phospho-alpha-D-ribose 1-diphosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+353  
Purine metabolism  hsa00230+353  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Purine salvage  definition   [KW-0660]
Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P07741
Other
GeneWiki: Adenine_phosphoribosyltransferase
GenomeRNAi: 353
PRO: PR:P07741