CD3E - T-cell surface glycoprotein CD3 epsilon chain - human protein (Function)
 
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CD3E »  T-cell surface glycoprotein CD3 epsilon chain
 
Protein also known as:  T-cell surface antigen T3/Leu-4 epsilon chain; CD antigen CD3e.
Gene name:  CD3E
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 113 1
GENE REF ISO

Function

 show evidences
Overview 
The CD3 complex mediates signal transduction.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • NASUniProtKB
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • NASUniProtKB
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • TASPINC
SH3 domain bindingdefinition[GO:0017124]  
1
  • IPIUniProtKB
T cell receptor bindingdefinition[GO:0042608]  
1
  • NASUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • NASUniProtKB
GO biological process 
Apoptotic signaling pathwaydefinition[GO:0097190] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • NASUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASGOC
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
  • IEAOrtholog Compara
Negative thymic T cell selectiondefinition[GO:0045060] silver  
  • IEAOrtholog Compara
Positive regulation of alpha-beta T cell proliferationdefinition[GO:0046641] silver  
  • IEAOrtholog Compara
Positive regulation of calcium-mediated signalingdefinition[GO:0050850] silver  
  • IEAOrtholog Compara
Positive regulation of interferon-gamma productiondefinition[GO:0032729] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-2 biosynthetic processdefinition[GO:0045086] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-4 productiondefinition[GO:0032753] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731] silver  
  • IEAOrtholog Compara
Positive regulation of T cell anergydefinition[GO:0002669] silver  
  • IEAOrtholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IMPUniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • NASUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • NASUniProtKB
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Signal complex assemblydefinition[GO:0007172]  
1
  • TASPINC
T cell activationdefinition[GO:0042110]  
1
  • NASUniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+916  
Hematopoietic cell lineage  hsa04640+916  
HTLV-I infection  hsa05166+916  
Measles  hsa05162+916  
Primary immunodeficiency  hsa05340+916  
T cell receptor signaling pathway  hsa04660+916  
According to Reactome, this protein belongs to the following pathways:
Downstream TCR signaling  REACT_12555  
Generation of second messenger molecules  REACT_12623  
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  REACT_11152  
PD-1 signaling  REACT_19324  
Phosphorylation of CD3 and TCR zeta chains  REACT_12582  
Translocation of ZAP-70 to Immunological synapse  REACT_12596  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: T-cell_surface_glycoprotein_CD3_epsilon_chain
GenomeRNAi: 916
PRO: PR:P07766
Chemistry
GuidetoPHARMACOLOGY: 2742