CTSB - Cathepsin B - human protein (Function)
 
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Protein
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CTSB »  Cathepsin B
 
Cleaved into:  Cathepsin B heavy chain; Cathepsin B light chain.
Gene name:  CTSB
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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1 196 1
GENE REF ISO

Function

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Overview 
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.  
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • IDABHF-UCL
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
2
  • IDABHF-UCL
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • IDAUniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Proteoglycan bindingdefinition[GO:0043394]  
1
  • IPIBHF-UCL
GO biological process 
Cellular response to thyroid hormone stimulusdefinition[GO:0097067]  
1
  • IEPUniProtKB
Collagen catabolic processdefinition[GO:0030574]  
1
  • IDABHF-UCL
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IEPUniProtKB
Proteolysisdefinition[GO:0006508]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IDABHF-UCL
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Regulation of catalytic activitydefinition[GO:0050790] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.1: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+1508  
Lysosome  hsa04142+1508  
According to Reactome, this protein belongs to the following pathways:
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Collagen degradation  REACT_150401  
MHC class II antigen presentation  REACT_121399  
Trafficking and processing of endosomal TLR  REACT_118632  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cathepsin_B
GenomeRNAi: 1508
PRO: PR:P07858
Chemistry
GuidetoPHARMACOLOGY: 2343