CTSB - Cathepsin B - human protein (Function)
 
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CTSB »  Cathepsin B   [ EC 3.4.22.1 ]
 
Protein also known as:  APP secretase (APPS). Cleaved into:  Cathepsin B heavy chain; Cathepsin B light chain.
Gene name:  CTSB
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.  
1
  • UniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • BHF-UCL
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
2
  • BHF-UCL
Cysteine-type peptidase activitydefinition[GO:0008234]  
2
  • UniProtKB
  • CACAO
Kininogen bindingdefinition[GO:0030984] silver  
1
  • Ortholog Compara
Peptidase activitydefinition[GO:0008233]  
1
  • BHF-UCL
Peptide bindingdefinition[GO:0042277] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
  • AgBase
  • BHF-UCL
Protein self-associationdefinition[GO:0043621] silver  
1
  • Ortholog Compara
Proteoglycan bindingdefinition[GO:0043394]  
1
  • BHF-UCL
GO biological process 
Autophagydefinition[GO:0006914] silver  
1
  • Ortholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
1
  • Ortholog Compara
Cellular response to thyroid hormone stimulusdefinition[GO:0097067]  
1
  • UniProtKB
Collagen catabolic processdefinition[GO:0030574]  
1
  • BHF-UCL
Decidualizationdefinition[GO:0046697] silver  
1
  • Ortholog Compara
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • UniProtKB
Negative regulation of cell deathdefinition[GO:0060548] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
2
  • UniProtKB
  • BHF-UCL
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • BHF-UCL
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • UniProtKB
Regulation of catalytic activitydefinition[GO:0050790] silver  
1
  • InterPro 2 GO
Response to aminedefinition[GO:0014075] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to glucosedefinition[GO:0009749] silver  
1
  • Ortholog Compara
Response to interleukin-4definition[GO:0070670] silver  
1
  • Ortholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Response to woundingdefinition[GO:0009611] silver  
1
  • Ortholog Compara
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Viral entry into host celldefinition[GO:0046718] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.1: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+1508  
Lysosome  hsa04142+1508  
According to Reactome, this protein belongs to the following pathways:
Assembly of collagen fibrils and other multimeric structures  R-HSA-2022090  
Collagen degradation  R-HSA-1442490  
MHC class II antigen presentation  R-HSA-2132295  
Trafficking and processing of endosomal TLR  R-HSA-1679131  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cathepsin_B
GenomeRNAi: 1508
PRO: PR:P07858
Chemistry
GuidetoPHARMACOLOGY: 2343