HSP90AA1 - Heat shock protein HSP 90-alpha - human protein (Function)
 
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HSP90AA1 »  Heat shock protein HSP 90-alpha
 
Protein also known as:  Lipopolysaccharide-associated protein 2 (LAP-2).
Gene name:  HSP90AA1
Family name: Heat shock protein 90
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.  
5
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
4
  • IntAct
MHC class II protein complex bindingdefinition[GO:0023026]  
1
  • UniProtKB
Nitric-oxide synthase regulator activitydefinition[GO:0030235]  
1
  • UniProtKB
Nucleotide bindingdefinition[GO:0000166]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
31
  • IntAct
  • UniProtKB
  • HGNC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
TPR domain bindingdefinition[GO:0030911]  
2
  • UniProtKB
Unfolded protein bindingdefinition[GO:0051082] silver  
1
  • InterPro 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • GOC
Chaperone-mediated protein complex assemblydefinition[GO:0051131]  
1
  • BHF-UCL
Mitochondrial transportdefinition[GO:0006839]  
1
  • UniProtKB
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • Ortholog Curator
Protein import into mitochondrial outer membranedefinition[GO:0045040]  
1
  • BHF-UCL
Protein refoldingdefinition[GO:0042026]  
1
  • UniProtKB
Response to unfolded proteindefinition[GO:0006986]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+3320  
NOD-like receptor signaling pathway  hsa04621+3320  
Pathways in cancer  hsa05200+3320  
Progesterone-mediated oocyte maturation  hsa04914+3320  
Prostate cancer  hsa05215+3320  
Protein processing in endoplasmic reticulum  hsa04141+3320  
According to Reactome, this protein belongs to the following pathways:
Attenuation phase  REACT_200624  
eNOS activation  REACT_12477  
EPHA-mediated growth cone collapse  REACT_228063  
HSF1 activation  REACT_200744  
HSF1-dependent transactivation  REACT_200775  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Scavenging by Class F Receptors  REACT_163813  
Sema3A PAK dependent Axon repulsion  REACT_19236  
Signaling by constitutively active EGFR  REACT_115852  
Signaling by ERBB2  REACT_115755  
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation  REACT_111176  
VEGFA-VEGFR2 Pathway  REACT_228166  
VEGFR2 mediated vascular permeability  REACT_228016  
vRNP Assembly  REACT_9434  
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3320
PRO: PR:P07900