HSP90AA1 - Heat shock protein HSP 90-alpha - human protein (Function)
 
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Protein
Gene
References

 
HSP90AA1 »  Heat shock protein HSP 90-alpha
 
Protein also known as:  Lipopolysaccharide-associated protein 2 (LAP-2).
Gene name:  HSP90AA1
Family name: Heat shock protein 90
Entry whose protein(s) existence is based on evidence at protein level
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1 491 2
GENE REF ISO

Function

 show evidences
Overview 
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.  
5
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
GTPase bindingdefinition[GO:0051020]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
4
  • IntAct
MHC class II protein complex bindingdefinition[GO:0023026]  
1
  • UniProtKB
Nitric-oxide synthase regulator activitydefinition[GO:0030235]  
1
  • UniProtKB
Nucleotide bindingdefinition[GO:0000166]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
32
  • IntAct
  • UniProtKB
  • HGNC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
TPR domain bindingdefinition[GO:0030911]  
2
  • UniProtKB
Unfolded protein bindingdefinition[GO:0051082] silver  
1
  • InterPro 2 GO
GO biological process 
Chaperone-mediated autophagydefinition[GO:0061684]  
1
  • ParkinsonsUK-UCL
Chaperone-mediated protein complex assemblydefinition[GO:0051131]  
1
  • BHF-UCL
Mitochondrial transportdefinition[GO:0006839]  
1
  • UniProtKB
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • Ortholog Curator
Protein import into mitochondrial outer membranedefinition[GO:0045040]  
1
  • BHF-UCL
Protein refoldingdefinition[GO:0042026]  
1
  • UniProtKB
Protein unfoldingdefinition[GO:0043335]  
1
  • ParkinsonsUK-UCL
Regulation of protein complex assemblydefinition[GO:0043254]  
1
  • ParkinsonsUK-UCL
Response to antibioticdefinition[GO:0046677]  
1
  • Ortholog Curator
Response to colddefinition[GO:0009409]  
1
  • Ortholog Curator
Response to heatdefinition[GO:0009408]  
1
  • Ortholog Curator
Response to unfolded proteindefinition[GO:0006986]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+3320  
NOD-like receptor signaling pathway  hsa04621+3320  
Pathways in cancer  hsa05200+3320  
Progesterone-mediated oocyte maturation  hsa04914+3320  
Prostate cancer  hsa05215+3320  
Protein processing in endoplasmic reticulum  hsa04141+3320  
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  R-HSA-5620912  
Attenuation phase  R-HSA-3371568  
Constitutive Signaling by EGFRvIII  R-HSA-5637810  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
eNOS activation  R-HSA-203615  
EPHA-mediated growth cone collapse  R-HSA-3928663  
HSF1 activation  R-HSA-3371511  
HSF1-dependent transactivation  R-HSA-3371571  
Loss of Nlp from mitotic centrosomes  R-HSA-380259  
PIWI-interacting RNA (piRNA) biogenesis  R-HSA-5601884  
Recruitment of mitotic centrosome proteins and complexes  R-HSA-380270  
Regulation of actin dynamics for phagocytic cup formation  R-HSA-2029482  
Regulation of PLK1 Activity at G2/M Transition  R-HSA-2565942  
Scavenging by Class F Receptors  R-HSA-3000484  
Sema3A PAK dependent Axon repulsion  R-HSA-399954  
Signaling by ERBB2  R-HSA-1227986  
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation  R-HSA-1474151  
Uptake and function of diphtheria toxin  R-HSA-5336415  
VEGFA-VEGFR2 Pathway  R-HSA-4420097  
VEGFR2 mediated vascular permeability  R-HSA-5218920  
vRNP Assembly  R-HSA-192905  
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
Chaperone  definition   [KW-0143]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3320
PRO: PR:P07900