GALT - Galactose-1-phosphate uridylyltransferase - human protein (Function)
 
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Protein
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References

 
GALT »  Galactose-1-phosphate uridylyltransferase   [ EC 2.7.7.12 ]  (Gal-1-P uridylyltransferase)
 
Protein also known as:  UDP-glucose--hexose-1-phosphate uridylyltransferase.
Gene name:  GALT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
UDP-glucose:hexose-1-phosphate uridylyltransferase activitydefinition[GO:0008108]  
  • IEAEC 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Galactose metabolic processdefinition[GO:0006012]  
1
  • TASPINC
UDP-glucose catabolic processdefinition[GO:0006258] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.7.12: UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 iron ion per subunit (Potential).  
  • CuratedUniProtKB
Binds 1 zinc ion per subunit (Potential).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+2592  
Galactose metabolism  hsa00052+2592  
Metabolic pathways  hsa01100+2592  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 1.25 mM for alpha-D-galactose 1-phosphate (at pH 8.7)
KM 0.43 mM for UDP-glucose (at pH 8.7)
Vmax 48 umol/min/mg enzyme

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Galactose metabolism  definition   [KW-0299]
Molecular function 
Nucleotidyltransferase  definition   [KW-0548]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P07902
Other
GeneWiki: Galactose%E2%80%941-phosphate_uridylyltransferase
GenomeRNAi: 2592
PRO: PR:P07902