UMOD - Uromodulin - human protein (Function)
 
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UMOD »  Uromodulin
 
Protein also known as:  Tamm-Horsfall urinary glycoprotein (THP). Cleaved into:  Uromodulin, secreted form.
Gene name:  UMOD
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.  
1
  • CuratedUniProtKB
Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Chemical homeostasisdefinition[GO:0048878] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588] silver  
  • IEAOrtholog Compara
Metanephric ascending thin limb developmentdefinition[GO:0072218] silver  
  • IEAOrtholog Compara
Metanephric distal convoluted tubule developmentdefinition[GO:0072221] silver  
  • IEAOrtholog Compara
Metanephric thick ascending limb developmentdefinition[GO:0072233] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Regulation of ion homeostasisdefinition[GO:2000021] silver  
  • IEAOrtholog Compara
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
Note 
A specific, but as yet unidentified, protease(s) cleaves off and releases UMOD into urine.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links