FH - Fumarate hydratase, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
FH »  Fumarate hydratase, mitochondrial   [ EC 4.2.1.2 ]  (Fumarase)
 
Gene name:  FH
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 2
GENE REF ISO

Function

 show evidences
Overview 
Also acts as a tumor suppressor.  
  • CuratedUniProtKB
GO biological process 
Fumarate metabolic processdefinition[GO:0006106] silver  
  • IEAInterPro 2 GO
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
  • IEAOrtholog Compara
Tricarboxylic acid cycledefinition[GO:0006099]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.2: (S)-malate fumarate + H(2)O.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+2271  
Metabolic pathways  hsa01100+2271  
Pathways in cancer  hsa05200+2271  
Renal cell carcinoma  hsa05211+2271  
According to Reactome, this protein belongs to the following pathway:
Citric acid cycle (TCA cycle)  REACT_1785  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2271
PRO: PR:P07954