SFTPB - Pulmonary surfactant-associated protein B - human protein (Function)
 
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SFTPB »  Pulmonary surfactant-associated protein B  (SP-B)
 
Protein also known as:  Pulmonary surfactant-associated proteolipid SPL(Phe).
Gene name:  SFTPB
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.  
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  • UniProtKB
GO molecular function 
Enzyme activator activitydefinition[GO:0008047]  
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  • RefGenome
G-protein coupled receptor bindingdefinition[GO:0001664]  
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  • RefGenome
GO biological process 
Organ morphogenesisdefinition[GO:0009887]  
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  • PINC
Positive regulation of catalytic activitydefinition[GO:0043085]  
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  • RefGenome
Respiratory gaseous exchangedefinition[GO:0007585]  
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  • UniProtKB KW
Sphingolipid metabolic processdefinition[GO:0006665] silver  
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  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathways:
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)  R-HSA-5688890  
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)  R-HSA-5688849  
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)  R-HSA-5688031  
Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)  R-HSA-5688354  
Surfactant metabolism  R-HSA-5683826  
Note 
Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).  
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  • UniProtKB
 

Keywords

Biological process 
Gaseous exchange  definition   [KW-0305]
Technical term 
Reference proteome  definition   [KW-1185]
 

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