ERCC1 - DNA excision repair protein ERCC-1 - human protein (Function)
 
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Protein
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ERCC1 »  DNA excision repair protein ERCC-1
 
Gene name:  ERCC1
Family name: ERCC1/RAD10/SWI10
Entry whose protein(s) existence is based on evidence at protein level
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1 294 4
GENE REF ISO

Function

 show evidences
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Single-stranded DNA bindingdefinition[GO:0003697]  
2
  • IDAUniProtKB
Contributes to single-stranded DNA endodeoxyribonuclease activitydefinition[GO:0000014]  
1
  • IDAUniProtKB
Contributes to structure-specific DNA bindingdefinition[GO:0043566]  
1
  • IDAUniProtKB
TBP-class protein bindingdefinition[GO:0017025] silver  
  • IEAOrtholog Compara
TFIID-class transcription factor bindingdefinition[GO:0001094] silver  
  • IEAOrtholog Compara
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Chromosome organizationdefinition[GO:0051276] silver  
  • IEAOrtholog Compara
DNA catabolic process, endonucleolyticdefinition[GO:0000737]  
1
  • IDAGOC
DNA recombinationdefinition[GO:0006310]  
1
  • IGIMGI
Double-strand break repairdefinition[GO:0006302] silver  
  • IEAOrtholog Compara
Embryonic organ developmentdefinition[GO:0048568] silver  
  • IEAOrtholog Compara
Isotype switchingdefinition[GO:0045190] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Mitotic recombinationdefinition[GO:0006312]  
1
  • IMPUniProtKB
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Multicellular organismal agingdefinition[GO:0010259] silver  
  • IEAOrtholog Compara
Negative regulation of telomere maintenancedefinition[GO:0032205]  
1
  • IMPUniProtKB
Nucleotide-excision repairdefinition[GO:0006289]  
2
  • IGIMGI
Nucleotide-excision repair, DNA incision, 3'-to lesiondefinition[GO:0006295]  
1
  • IMPUniProtKB
Nucleotide-excision repair, DNA incision, 5'-to lesiondefinition[GO:0006296]  
1
  • IMPUniProtKB
Oogenesisdefinition[GO:0048477] silver  
  • IEAOrtholog Compara
Post-embryonic hemopoiesisdefinition[GO:0035166] silver  
  • IEAOrtholog Compara
Pyrimidine dimer repair by nucleotide-excision repairdefinition[GO:0000720] silver  
  • IEAOrtholog Compara
Replicative cell agingdefinition[GO:0001302] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979]  
2
  • IMPUniProtKB
Response to sucrosedefinition[GO:0009744] silver  
  • IEAOrtholog Compara
Response to X-raydefinition[GO:0010165] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Syncytium formationdefinition[GO:0006949] silver  
  • IEAOrtholog Compara
UV protectiondefinition[GO:0009650] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fanconi anemia pathway  hsa03460+2067  
Nucleotide excision repair  hsa03420+2067  
According to Reactome, this protein belongs to the following pathways:
Dual incision reaction in GG-NER  REACT_311  
Dual incision reaction in TC-NER  REACT_2222  
Formation of incision complex in GG-NER  REACT_257  
Formation of transcription-coupled NER (TC-NER) repair complex  REACT_1941  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Endonuclease  definition   [KW-0255]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ERCC1
GenomeRNAi: 2067
PRO: PR:P07992