THBS1 - Thrombospondin-1 - human protein (Function)
 
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Protein
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THBS1 »  Thrombospondin-1
 
Gene name:  THBS1
Family name: Thrombospondin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • NASBHF-UCL
Collagen V bindingdefinition[GO:0070052]  
1
  • IDABHF-UCL
Fibrinogen bindingdefinition[GO:0070051]  
1
  • IDABHF-UCL
Fibroblast growth factor bindingdefinition[GO:0017134]  
1
  • IDABHF-UCL
Fibronectin bindingdefinition[GO:0001968]  
1
  • IDABHF-UCL
Glycoprotein bindingdefinition[GO:0001948]  
1
  • NASBHF-UCL
Heparin bindingdefinition[GO:0008201]  
2
  • IDAMGI
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • NASBHF-UCL
Integrin bindingdefinition[GO:0005178]  
2
  • IMPBHF-UCL
Laminin bindingdefinition[GO:0043236]  
1
  • IDABHF-UCL
Low-density lipoprotein particle bindingdefinition[GO:0030169]  
1
  • IDABHF-UCL
Phosphatidylserine bindingdefinition[GO:0001786]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
Proteoglycan bindingdefinition[GO:0043394]  
1
  • TASBHF-UCL
Transforming growth factor beta bindingdefinition[GO:0050431]  
1
  • TASBHF-UCL
  • ISSOrtholog Curator
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IMPBHF-UCL
Behavioral response to paindefinition[GO:0048266]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • NASBHF-UCL
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDABHF-UCL
Cell migrationdefinition[GO:0016477]  
1
  • IDABHF-UCL
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
Cellular response to heatdefinition[GO:0034605]  
1
  • NASBHF-UCL
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Chronic inflammatory responsedefinition[GO:0002544]  
1
  • IEPBHF-UCL
Endocardial cushion developmentdefinition[GO:0003197] silver  
  • IEAOrtholog Compara
Engulfment of apoptotic celldefinition[GO:0043652]  
1
  • IDABHF-UCL
Growth plate cartilage developmentdefinition[GO:0003417] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • IEPBHF-UCL
Negative regulation of angiogenesisdefinition[GO:0016525]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIdefinition[GO:0002581]  
1
  • IDABHF-UCL
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • IDABHF-UCL
Negative regulation of cell-matrix adhesiondefinition[GO:0001953]  
1
  • IDABHF-UCL
Negative regulation of cGMP-mediated signalingdefinition[GO:0010754]  
1
  • IDABHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IDAUniProtKB
Negative regulation of dendritic cell antigen processing and presentationdefinition[GO:0002605]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell migrationdefinition[GO:0010596]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
2
  • IDABHF-UCL
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • TASBHF-UCL
Negative regulation of fibrinolysisdefinition[GO:0051918]  
1
  • IDABHF-UCL
Negative regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040037]  
1
  • IDABHF-UCL
Negative regulation of focal adhesion assemblydefinition[GO:0051895]  
1
  • TASBHF-UCL
Negative regulation of interleukin-12 productiondefinition[GO:0032695]  
1
  • IDABHF-UCL
Negative regulation of nitric oxide mediated signal transductiondefinition[GO:0010751]  
1
  • IDABHF-UCL
Negative regulation of plasma membrane long-chain fatty acid transportdefinition[GO:0010748]  
1
  • IDABHF-UCL
Negative regulation of plasminogen activationdefinition[GO:0010757]  
1
  • IDABHF-UCL
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Peptide cross-linkingdefinition[GO:0018149]  
1
  • IDABHF-UCL
Positive regulation of angiogenesisdefinition[GO:0045766]  
2
  • IMPBHF-UCL
Positive regulation of blood coagulationdefinition[GO:0030194]  
1
  • IDABHF-UCL
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
2
  • IMPBHF-UCL
Positive regulation of cell-substrate adhesiondefinition[GO:0010811] silver  
  • IEAOrtholog Compara
Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • IDABHF-UCL
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353]  
1
  • IDAUniProtKB
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • IDABHF-UCL
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902043]  
1
  • IDABHF-UCL
Positive regulation of fibroblast migrationdefinition[GO:0010763]  
1
  • IDABHF-UCL
Positive regulation of macrophage activationdefinition[GO:0043032]  
1
  • IDABHF-UCL
Positive regulation of macrophage chemotaxisdefinition[GO:0010759]  
  • ISSOrtholog Curator
Positive regulation of phosphorylationdefinition[GO:0042327]  
1
  • IMPBHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDAUniProtKB
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • IDABHF-UCL
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511]  
1
  • IDABHF-UCL
Positive regulation of transforming growth factor beta1 productiondefinition[GO:0032914]  
  • ISSOrtholog Curator
Positive regulation of translationdefinition[GO:0045727]  
1
  • IDABHF-UCL
Positive regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042535]  
1
  • IDAUniProtKB
Response to calcium iondefinition[GO:0051592]  
2
  • IDABHF-UCL
Response to drugdefinition[GO:0042493]  
1
  • IEPUniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
  • ISSOrtholog Curator
Response to glucosedefinition[GO:0009749]  
1
  • IDABHF-UCL
Response to hypoxiadefinition[GO:0001666]  
1
  • NASBHF-UCL
Response to magnesium iondefinition[GO:0032026]  
1
  • IDABHF-UCL
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to progesteronedefinition[GO:0032570]  
1
  • TASBHF-UCL
Response to testosteronedefinition[GO:0033574] silver  
  • IEAOrtholog Compara
Response to unfolded proteindefinition[GO:0006986]  
  • IEAUniProtKB KW
Sprouting angiogenesisdefinition[GO:0002040]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bladder cancer  hsa05219+7057  
ECM-receptor interaction  hsa04512+7057  
Focal adhesion  hsa04510+7057  
Malaria  hsa05144+7057  
p53 signaling pathway  hsa04115+7057  
Phagosome  hsa04145+7057  
TGF-beta signaling pathway  hsa04350+7057  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Unfolded protein response  definition   [KW-0834]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Thrombospondin_1
GenomeRNAi: 7057
PRO: PR:P07996