GJB1 - Gap junction beta-1 protein - human protein (Function)
 
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Protein
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GJB1 »  Gap junction beta-1 protein
 
Protein also known as:  GAP junction 28 kDa liver protein.
Gene name:  GJB1
Family name: Connexin » Beta-type (group I)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the gap junction-forming connexin (connexin) family  1.A.24.1.3  
GO molecular function 
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Gap junction assembly  REACT_9509  
Oligomerization of connexins into connexons  REACT_9398  
Transport of connexins along the secretory pathway  REACT_9392  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GJB1
GenomeRNAi: 2705
PRO: PR:P08034
Chemistry
GuidetoPHARMACOLOGY: 723