SP1 - Transcription factor Sp1 - human protein (Function)
 
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SP1 »  Transcription factor Sp1
 
Gene name:  SP1
Entry whose protein(s) existence is based on evidence at protein level
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1 563 1
GENE REF ISO

Function

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Overview 
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.  
15
  • CuratedUniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
  • ISSOrtholog Curator
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • IDABHF-UCL
Enhancer bindingdefinition[GO:0035326] silver  
  • IEAOrtholog Compara
Histone acetyltransferase bindingdefinition[GO:0035035] silver  
  • IEAOrtholog Compara
Histone deacetylase bindingdefinition[GO:0042826]  
2
  • IPIBHF-UCL
HMG box domain bindingdefinition[GO:0071837]  
1
  • IPIUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
19
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
  • IEAOrtholog Compara
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
  • ISSOrtholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAHGNC
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDAUniProtKB
  • IDAHGNC
Transcription factor bindingdefinition[GO:0008134]  
2
  • IPIUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
2
  • IDABHF-UCL
GO biological process 
Definitive hemopoiesisdefinition[GO:0060216] silver  
  • IEAOrtholog Compara
Embryonic camera-type eye morphogenesisdefinition[GO:0048596] silver  
  • IEAOrtholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Embryonic process involved in female pregnancydefinition[GO:0060136] silver  
  • IEAOrtholog Compara
Embryonic skeletal system developmentdefinition[GO:0048706] silver  
  • IEAOrtholog Compara
Enucleate erythrocyte differentiationdefinition[GO:0043353] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Megakaryocyte differentiationdefinition[GO:0030219] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503] silver  
  • IEAOrtholog Compara
Positive regulation by host of viral transcriptiondefinition[GO:0043923]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • IDAUniProtKB
  • IDAHGNC
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAMGI
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • IDAUniProtKB
  • IDAHGNC
Trophectodermal cell differentiationdefinition[GO:0001829] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Disease  REACT_116125  
Gene Expression  REACT_71  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
Note 
In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the duplication of exons 2 and 3.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Sp1_transcription_factor
GenomeRNAi: 6667
PRO: PR:P08047