SP1 - Transcription factor Sp1 - human protein (Function)
 
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SP1 »  Transcription factor Sp1
 
Gene name:  SP1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.  
16
  • UniProtKB
Isoform  Iso 3   Is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.  
17
  • UniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
1
  • Ortholog Curator
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
1
  • Ortholog Curator
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • BHF-UCL
Enhancer bindingdefinition[GO:0035326] silver  
1
  • Ortholog Compara
Histone acetyltransferase bindingdefinition[GO:0035035] silver  
1
  • Ortholog Compara
Histone deacetylase bindingdefinition[GO:0042826]  
2
  • BHF-UCL
HMG box domain bindingdefinition[GO:0071837]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • Ortholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
1
  • Ortholog Compara
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • Ortholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • HGNC
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • RefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • UniProtKB
  • HGNC
Transcription factor bindingdefinition[GO:0008134]  
2
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
2
  • BHF-UCL
GO biological process 
Definitive hemopoiesisdefinition[GO:0060216] silver  
1
  • Ortholog Compara
Embryonic camera-type eye morphogenesisdefinition[GO:0048596] silver  
1
  • Ortholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
1
  • Ortholog Compara
Embryonic process involved in female pregnancydefinition[GO:0060136] silver  
1
  • Ortholog Compara
Embryonic skeletal system developmentdefinition[GO:0048706] silver  
1
  • Ortholog Compara
Enucleate erythrocyte differentiationdefinition[GO:0043353] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Megakaryocyte differentiationdefinition[GO:0030219] silver  
1
  • Ortholog Compara
Ossificationdefinition[GO:0001503] silver  
1
  • Ortholog Compara
Positive regulation by host of viral transcriptiondefinition[GO:0043923]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • UniProtKB
  • HGNC
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • MGI
  • UniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • UniProtKB
  • HGNC
Rhythmic processdefinition[GO:0048511]  
1
  • UniProtKB KW
Trophectodermal cell differentiationdefinition[GO:0001829] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  REACT_147904  
Oncogene Induced Senescence  REACT_169325  
PPARA activates gene expression  REACT_116145  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
Note 
In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the duplication of exons 2 and 3.  
1
  • UniProtKB
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Sp1_transcription_factor
GenomeRNAi: 6667
PRO: PR:P08047