RHO - Rhodopsin - human protein (Function)
 
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Protein
Gene
References

 
RHO »  Rhodopsin
 
Gene name:  RHO
Entry whose protein(s) existence is based on evidence at protein level
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1 136 1
GENE REF ISO

Function

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Overview 
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.1.2  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Photoreceptor activitydefinition[GO:0009881]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Retinal bindingdefinition[GO:0016918] silver  
  • IEAOrtholog Compara
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Protein-chromophore linkagedefinition[GO:0018298]  
  • IEAUniProtKB KW
Red, far-red light phototransductiondefinition[GO:0009585] silver  
  • IEAOrtholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Visual perceptiondefinition[GO:0007601] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Phototransduction  hsa04744+6010  
According to Reactome, this protein belongs to the following pathways:
Activation of the phototransduction cascade  REACT_163932  
G alpha (i) signalling events  REACT_19231  
Inactivation, recovery and regulation of the phototransduction cascade  REACT_163919  
Opsins  REACT_18426  
The canonical retinoid cycle in rods (twilight vision)  REACT_160156  
 

Biophysicochemical properties

Absorption
Abs(max) 495 nm

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Photoreceptor protein  definition   [KW-0600]
Receptor  definition   [KW-0675]
Retinal protein  definition   [KW-0681]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Rhodopsin
GenomeRNAi: 6010
PRO: PR:P08100