RHO - Rhodopsin - human protein (Function)
 
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Protein
Gene
References

 
RHO »  Rhodopsin
 
Protein also known as:  Opsin-2.
Gene name:  RHO
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.1.2  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Photoreceptor activitydefinition[GO:0009881]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
GO biological process 
Absorption of visible lightdefinition[GO:0016038]  
1
  • Ortholog Curator
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Photoreceptor cell maintenancedefinition[GO:0045494] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • Ortholog Compara
Protein-chromophore linkagedefinition[GO:0018298]  
1
  • UniProtKB KW
Retina development in camera-type eyedefinition[GO:0060041] silver  
1
  • Ortholog Compara
Visual perceptiondefinition[GO:0007601] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Phototransduction  hsa04744+6010  
According to Reactome, this protein belongs to the following pathways:
Activation of the phototransduction cascade  R-HSA-2485179  
G alpha (i) signalling events  R-HSA-418594  
Inactivation, recovery and regulation of the phototransduction cascade  R-HSA-2514859  
Opsins  R-HSA-419771  
The canonical retinoid cycle in rods (twilight vision)  R-HSA-2453902  
VxPx cargo-targeting to cilium  R-HSA-5620916  
 

Biophysicochemical properties

Absorption
Abs(max) 495 nm

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Photoreceptor protein  definition   [KW-0600]
Receptor  definition   [KW-0675]
Retinal protein  definition   [KW-0681]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Rhodopsin
GenomeRNAi: 6010
PRO: PR:P08100