HSPA1B - Heat shock 70 kDa protein 1A/1B - human protein (Function)
 
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HSPA1A »  Heat shock 70 kDa protein 1A/1B
 
Protein also known as:  Heat shock 70 kDa protein 1/2 (HSP70-1/HSP70-2).
Gene name:  HSPA1A ; HSPA1B
Family name: Heat shock protein 70
Entry whose protein(s) existence is based on evidence at protein level
extend overview
9 274 2
GENE REF ISO

Function

 show evidences
Overview 
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the cation channel-forming heat shock protein-70 (hsp70) family  1.A.33.1.3  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDABHF-UCL
ATPase activitydefinition[GO:0016887]  
1
  • IDABHF-UCL
ATPase activity, coupleddefinition[GO:0042623]  
1
  • IDAUniProtKB
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • IDAMGI
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Heat shock protein bindingdefinition[GO:0031072]  
2
  • IPIBHF-UCL
  • IPIUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein binding involved in protein foldingdefinition[GO:0044183]  
1
  • IDABHF-UCL
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIBHF-UCL
Unfolded protein bindingdefinition[GO:0051082]  
2
  • IDAUniProtKB
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Cellular heat acclimationdefinition[GO:0070370]  
1
  • IMPUniProtKB
Cellular response to heatdefinition[GO:0034605]  
1
  • IDAUniProtKB
mRNA catabolic processdefinition[GO:0006402]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
2
  • IMPUniProtKB
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IMPUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPUniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • IMPBHF-UCL
Negative regulation of inclusion body assemblydefinition[GO:0090084]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • IMPUniProtKB
Protein refoldingdefinition[GO:0042026]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Not  Regulation of cell deathdefinition[GO:0010941]  
1
  • IMPUniProtKB
Response to unfolded proteindefinition[GO:0006986]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+3303  
Antigen processing and presentation  hsa04612+3304  
Endocytosis  hsa04144+3304  
Endocytosis  hsa04144+3303  
Influenza A  hsa05164+3304  
Influenza A  hsa05164+3303  
Legionellosis  hsa05134+3303  
Legionellosis  hsa05134+3304  
MAPK signaling pathway  hsa04010+3304  
MAPK signaling pathway  hsa04010+3303  
Measles  hsa05162+3303  
Measles  hsa05162+3304  
Prion diseases  hsa05020+3303  
Protein processing in endoplasmic reticulum  hsa04141+3304  
Protein processing in endoplasmic reticulum  hsa04141+3303  
Spliceosome  hsa03040+3304  
Spliceosome  hsa03040+3303  
Toxoplasmosis  hsa05145+3304  
Toxoplasmosis  hsa05145+3303  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Gene Expression  REACT_71  
Metabolism of RNA  REACT_21257  
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
Chaperone  definition   [KW-0143]
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HSPA1A
PRO: PR:P08107