HSPA1A - Heat shock 70 kDa protein 1A/1B - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
HSPA1A »  Heat shock 70 kDa protein 1A/1B
 
Protein also known as:  Heat shock 70 kDa protein 1/2 (HSP70.1/HSP70.2).
Gene name:  HSPA1A ; HSPA1B
Family name: Heat shock protein 70
Entry whose protein(s) existence is based on evidence at protein level
extend overview
2 309 2
GENE REF ISO

Function

 show evidences
Overview 
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed23973223).  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the cation channel-forming heat shock protein-70 (hsp70) family  1.A.33.1.3  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • BHF-UCL
ATPase activitydefinition[GO:0016887]  
2
  • CACAO
  • BHF-UCL
ATPase activity, coupleddefinition[GO:0042623]  
1
  • UniProtKB
C3HC4-type RING finger domain bindingdefinition[GO:0055131]  
1
  • BHF-UCL
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • MGI
Enzyme bindingdefinition[GO:0019899]  
1
  • BHF-UCL
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • ParkinsonsUK-UCL
Heat shock protein bindingdefinition[GO:0031072]  
2
  • BHF-UCL
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
28
  • IntAct
  • UniProtKB
  • ParkinsonsUK-UCL
  • AgBase
  • BHF-UCL
Protein binding involved in protein foldingdefinition[GO:0044183]  
1
  • BHF-UCL
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
2
  • BHF-UCL
  • ParkinsonsUK-UCL
Unfolded protein bindingdefinition[GO:0051082]  
3
  • UniProtKB
  • ParkinsonsUK-UCL
Virus receptor activitydefinition[GO:0001618]  
1
  • UniProtKB KW
GO biological process 
Cellular heat acclimationdefinition[GO:0070370]  
1
  • UniProtKB
Cellular response to heatdefinition[GO:0034605]  
1
  • UniProtKB
Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • ParkinsonsUK-UCL
mRNA catabolic processdefinition[GO:0006402]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
2
  • UniProtKB
Negative regulation of cell deathdefinition[GO:0060548]  
2
  • UniProtKB
  • ParkinsonsUK-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • UniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902236]  
1
  • ParkinsonsUK-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • BHF-UCL
Negative regulation of inclusion body assemblydefinition[GO:0090084]  
2
  • UniProtKB
  • BHF-UCL
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaydefinition[GO:1901029]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein ubiquitinationdefinition[GO:0031397]  
1
  • ParkinsonsUK-UCL
Positive regulation of endoribonuclease activitydefinition[GO:1902380]  
1
  • ParkinsonsUK-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • UniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • BHF-UCL
Positive regulation of IRE1-mediated unfolded protein responsedefinition[GO:1903896]  
1
  • ParkinsonsUK-UCL
Positive regulation of mRNA cleavagedefinition[GO:0031439]  
1
  • ParkinsonsUK-UCL
Protein refoldingdefinition[GO:0042026]  
2
  • UniProtKB
  • BHF-UCL
Protein stabilizationdefinition[GO:0050821]  
1
  • ParkinsonsUK-UCL
Not  Regulation of cell deathdefinition[GO:0010941]  
1
  • UniProtKB
Response to unfolded proteindefinition[GO:0006986]  
1
  • UniProtKB
Viral entry into host celldefinition[GO:0046718]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+3303  
Antigen processing and presentation  hsa04612+3304  
Endocytosis  hsa04144+3304  
Endocytosis  hsa04144+3303  
Influenza A  hsa05164+3304  
Influenza A  hsa05164+3303  
Legionellosis  hsa05134+3303  
Legionellosis  hsa05134+3304  
MAPK signaling pathway  hsa04010+3304  
MAPK signaling pathway  hsa04010+3303  
Measles  hsa05162+3303  
Measles  hsa05162+3304  
Prion diseases  hsa05020+3303  
Protein processing in endoplasmic reticulum  hsa04141+3304  
Protein processing in endoplasmic reticulum  hsa04141+3303  
Spliceosome  hsa03040+3304  
Spliceosome  hsa03040+3303  
Toxoplasmosis  hsa05145+3304  
Toxoplasmosis  hsa05145+3303  
According to Reactome, this protein belongs to the following pathways:
Attenuation phase  REACT_264075  
AUF1 (hnRNP D0) destabilizes mRNA  REACT_25325  
HSF1-dependent transactivation  REACT_264164  
Regulation of HSF1-mediated heat shock response  REACT_264487  
Viral RNP Complexes in the Host Cell Nucleus  REACT_6198  
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Molecular function 
Chaperone  definition   [KW-0143]
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HSPA1A
PRO: PR:P08107