COL1A2 - Collagen alpha-2(I) chain - human protein (Function)
 
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COL1A2 »  Collagen alpha-2(I) chain
 
Protein also known as:  Alpha-2 type I collagen.
Gene name:  COL1A2
Family name: Fibrillar collagen
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 204 1
GENE REF ISO

Function

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Overview 
Type I collagen is a member of group I collagen (fibrillar forming collagen).  
  • CuratedUniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201]  
1
  • NASUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Platelet-derived growth factor bindingdefinition[GO:0048407]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • IMPUniProtKB
SMAD bindingdefinition[GO:0046332] silver  
  • IEAOrtholog Compara
GO biological process 
Blood vessel developmentdefinition[GO:0001568]  
1
  • IMPUniProtKB
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Collagen fibril organizationdefinition[GO:0030199]  
2
  • IMPUniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • NASUniProtKB
Protein heterotrimerizationdefinition[GO:0070208] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217]  
1
  • IMPUniProtKB
Rho protein signal transductiondefinition[GO:0007266]  
1
  • IDAUniProtKB
Skeletal system developmentdefinition[GO:0001501]  
3
  • IMPUniProtKB
Skin morphogenesisdefinition[GO:0043589]  
1
  • IMPUniProtKB
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1278  
ECM-receptor interaction  hsa04512+1278  
Focal adhesion  hsa04510+1278  
Protein digestion and absorption  hsa04974+1278  
According to Reactome, this protein belongs to the following pathways:
Anchoring fibril formation  REACT_150268  
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Cell surface interactions at the vascular wall  REACT_12051  
Collagen biosynthesis and modifying enzymes  REACT_121139  
Collagen degradation  REACT_150401  
Crosslinking of collagen fibrils  REACT_150206  
ECM proteoglycans  REACT_163906  
Extracellular matrix organization  REACT_118779  
GPVI-mediated activation cascade  REACT_1695  
Integrin cell surface interactions  REACT_13552  
Non-integrin membrane-ECM interactions  REACT_163874  
Platelet Adhesion to exposed collagen  REACT_1230  
Scavenging by Class A Receptors  REACT_163699  
Syndecan interactions  REACT_163942  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: COL1A2
GenomeRNAi: 1278
PRO: PR:P08123