CHRM4 - Muscarinic acetylcholine receptor M4 - human protein (Function)
 
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Protein
Gene
References

 
CHRM4 »  Muscarinic acetylcholine receptor M4
 
Gene name:  CHRM4
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.  
1
  • UniProtKB
GO molecular function 
G-protein coupled acetylcholine receptor activitydefinition[GO:0016907] silver  
1
  • Ortholog Compara
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007197]  
1
  • RefGenome
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213]  
1
  • PINC
Phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007207]  
1
  • RefGenome
Not  Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • RefGenome
Regulation of locomotiondefinition[GO:0040012] silver  
1
  • InterPro 2 GO
Sensory perception of chemical stimulusdefinition[GO:0007606]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Synaptic transmission, cholinergicdefinition[GO:0007271]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+1132  
Neuroactive ligand-receptor interaction  hsa04080+1132  
Regulation of actin cytoskeleton  hsa04810+1132  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Muscarinic acetylcholine receptors  REACT_16943  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Muscarinic_acetylcholine_receptor_M4
GenomeRNAi: 1132
PRO: PR:P08173
Chemistry
GuidetoPHARMACOLOGY: 16