CHRM4 - Muscarinic acetylcholine receptor M4 - human protein (Function)
 
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Protein
Gene
References

 
CHRM4 »  Muscarinic acetylcholine receptor M4
 
Gene name:  CHRM4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled acetylcholine receptor activitydefinition[GO:0016907] silver  
  • IEAOrtholog Compara
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007197] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213]  
1
  • TASPINC
Regulation of locomotiondefinition[GO:0040012] silver  
  • IEAInterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+1132  
Neuroactive ligand-receptor interaction  hsa04080+1132  
Regulation of actin cytoskeleton  hsa04810+1132  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Muscarinic_acetylcholine_receptor_M4
GenomeRNAi: 1132
PRO: PR:P08173
Chemistry
GuidetoPHARMACOLOGY: 16