CD55 - Complement decay-accelerating factor - human protein (Function)
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CD55 »  Complement decay-accelerating factor
Protein also known as:  CD antigen CD55.
Gene name:  CD55
Entry whose protein(s) existence is based on evidence at protein level
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This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.  
  • CuratedUniProtKB
GO molecular function 
Enzyme inhibitor activitydefinition[GO:0004857] silver  
  • IEAOrtholog Compara
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
GO biological process 
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Maternal process involved in parturitiondefinition[GO:0060137] silver  
  • IEAOrtholog Compara
Negative regulation of complement activationdefinition[GO:0045916] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
  • IDAUniProtKB
Respiratory burstdefinition[GO:0045730]  
  • NASUniProtKB
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+1604  
Hematopoietic cell lineage  hsa04640+1604  
Viral myocarditis  hsa05416+1604  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Signal Transduction  REACT_111102  


Biological process 
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Blood group antigen  definition   [KW-0095]
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Decay-accelerating_factor
GenomeRNAi: 1604
PRO: PR:P08174