CD55 - Complement decay-accelerating factor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CD55 »  Complement decay-accelerating factor
 
Protein also known as:  CD antigen CD55.
Gene name:  CD55
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 64 7
GENE REF ISO

Function

 show evidences
Overview 
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.  
1
  • CuratedUniProtKB
GO molecular function 
Enzyme inhibitor activitydefinition[GO:0004857] silver  
  • IEAOrtholog Compara
Lipid bindingdefinition[GO:0008289]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Virus receptor activitydefinition[GO:0001618]  
1
  • IDAUniProtKB
GO biological process 
CD4-positive, alpha-beta T cell cytokine productiondefinition[GO:0035743]  
1
  • IDAUniProtKB
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Maternal process involved in parturitiondefinition[GO:0060137] silver  
  • IEAOrtholog Compara
Negative regulation of complement activationdefinition[GO:0045916]  
1
  • IDAUniProtKB
Positive regulation of CD4-positive, alpha-beta T cell activationdefinition[GO:2000516]  
1
  • IDAUniProtKB
Positive regulation of CD4-positive, alpha-beta T cell proliferationdefinition[GO:2000563]  
1
  • IDAUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Regulation of lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031664]  
1
  • IDAUniProtKB
Respiratory burstdefinition[GO:0045730]  
1
  • NASUniProtKB
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Response to virusdefinition[GO:0009615]  
1
  • IDAGOC
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+1604  
Hematopoietic cell lineage  hsa04640+1604  
Viral myocarditis  hsa05416+1604  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Blood group antigen  definition   [KW-0095]
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Decay-accelerating_factor
GenomeRNAi: 1604
PRO: PR:P08174