ABCB1 - Multidrug resistance protein 1 - human protein (Function)
 
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Protein
Gene
References

 
ABCB1 »  Multidrug resistance protein 1   [ EC 3.6.3.44 ]
 
Protein also known as:  ATP-binding cassette sub-family B member 1; CD antigen CD243.
Gene name:  ABCB1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 909 1
GENE REF ISO

Function

 show evidences
Overview 
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.201.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Transporter activitydefinition[GO:0005215]  
1
  • TASPINC
Xenobiotic-transporting ATPase activitydefinition[GO:0008559]  
  • IEAEC 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
  • IBARefGenome
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
1
  • IDADFLAT
Response to drugdefinition[GO:0042493]  
1
  • TASPINC
Stem cell proliferationdefinition[GO:0072089]  
1
  • IMPDFLAT
Transmembrane transportdefinition[GO:0055085] silver  
  • IBARefGenome
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.44: ATP + H(2)O + xenobiotic(In) ADP + phosphate + xenobiotic(Out).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+5243  
Bile secretion  hsa04976+5243  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: P-glycoprotein
GenomeRNAi: 5243
PRO: PR:P08183