NR3C2 - Mineralocorticoid receptor - human protein (Function)
 
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Protein
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References

 
NR3C2 »  Mineralocorticoid receptor  (MR)
 
Protein also known as:  Nuclear receptor subfamily 3 group C member 2.
Gene name:  NR3C2
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
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1 143 4
GENE REF ISO

Function

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Overview 
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Steroid bindingdefinition[GO:0005496]  
  • IEAUniProtKB KW
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aldosterone-regulated sodium reabsorption  hsa04960+4306  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Mineralocorticoid_receptor
GenomeRNAi: 4306
PRO: PR:P08235
Chemistry
GuidetoPHARMACOLOGY: 626