GUSB - Beta-glucuronidase - human protein (Function)
 
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Protein
Gene
References

 
GUSB »  Beta-glucuronidase   [ EC 3.2.1.31 ]
 
Protein also known as:  Beta-G1.
Gene name:  GUSB
Family name: Glycosyl hydrolase 2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the degradation of dermatan and keratan sulfates.  
  • CuratedUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.31: A beta-D-glucuronoside + H(2)O D-glucuronate + an alcohol.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by L-aspartic acid.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 2  GH2  
Pathways 
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - other enzymes  hsa00983+2990  
Glycosaminoglycan degradation  hsa00531+2990  
Lysosome  hsa04142+2990  
Metabolic pathways  hsa01100+2990  
Pentose and glucuronate interconversions  hsa00040+2990  
Porphyrin and chlorophyll metabolism  hsa00860+2990  
Starch and sucrose metabolism  hsa00500+2990  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GUSB
GenomeRNAi: 2990
PRO: PR:P08236