PFKM - 6-phosphofructokinase, muscle type - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PFKM »  6-phosphofructokinase, muscle type   [ EC 2.7.1.11 ]
 
Protein also known as:  Phosphofructo-1-kinase isozyme A (PFK-A).
Gene name:  PFKM
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 47 3
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.  
  • CuratedUniProtKB
GO molecular function 
6-phosphofructokinase activitydefinition[GO:0003872]  
3
  • IDABHF-UCL
  • IMPUniProtKB
  • ISSOrtholog Curator
ATP bindingdefinition[GO:0005524]  
1
  • IDABHF-UCL
Fructose bindingdefinition[GO:0070061]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Kinase bindingdefinition[GO:0019900]  
1
  • IPIBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIHGNC
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIHGNC
GO biological process 
Carbohydrate phosphorylationdefinition[GO:0046835]  
3
  • IDAGOC
  • ISSOrtholog Curator
Fructose 6-phosphate metabolic processdefinition[GO:0006002]  
2
  • IMPBHF-UCL
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Glycolytic processdefinition[GO:0006096]  
1
  • IMPUniProtKB
  • IEAUniPathway
Muscle cell cellular homeostasisdefinition[GO:0046716]  
1
  • IMPBHF-UCL
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
  • IEAOrtholog Compara
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.11: ATP + D-fructose 6-phosphate ADP + D-fructose 1,6-bisphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Allosteric enzyme activated by ADP, AMP, or fructose 2,6-bisphosphate and inhibited by ATP or citrate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fructose and mannose metabolism  hsa00051+5213  
Galactose metabolism  hsa00052+5213  
Glycolysis / Gluconeogenesis  hsa00010+5213  
Metabolic pathways  hsa01100+5213  
Pentose phosphate pathway  hsa00030+5213  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
Note 
In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P08237
Other
GeneWiki: PFKM
GenomeRNAi: 5213
PRO: PR:P08237