PFKM - ATP-dependent 6-phosphofructokinase, muscle type - human protein (Function)
 
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PFKM »  ATP-dependent 6-phosphofructokinase, muscle type   [ EC 2.7.1.11 ]  (PFK-M)
 
Protein also known as:  Phosphofructo-1-kinase isozyme A (PFK-A).
Gene name:  PFKM
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 3
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.  
1
  • UniProtKB
GO molecular function 
6-phosphofructokinase activitydefinition[GO:0003872]  
4
  • BHF-UCL
  • UniProtKB
  • Ortholog Curator
ATP bindingdefinition[GO:0005524]  
1
  • BHF-UCL
Fructose bindingdefinition[GO:0070061]  
1
  • BHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Kinase bindingdefinition[GO:0019900]  
1
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • HGNC
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • HGNC
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
GO biological process 
Carbohydrate phosphorylationdefinition[GO:0046835]  
7
  • GOC
  • InterPro 2 GO
  • Ortholog Curator
  • EC 2 GO
  • Ortholog Compara
Fructose 6-phosphate metabolic processdefinition[GO:0006002]  
2
  • BHF-UCL
Glucose homeostasisdefinition[GO:0042593] silver  
1
  • Ortholog Compara
Glycolytic processdefinition[GO:0006096]  
2
  • UniProtKB
  • UniPathway
Muscle cell cellular homeostasisdefinition[GO:0046716]  
1
  • BHF-UCL
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
1
  • Ortholog Compara
Protein oligomerizationdefinition[GO:0051259]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.11: ATP + D-fructose 6-phosphate ADP + D-fructose 1,6-bisphosphate.  
2
  • UniProtKB
  • HAMAP-Rule
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4  
2
  • UniProtKB
  • HAMAP-Rule
According to KEGG, this protein belongs to the following pathways:
Fructose and mannose metabolism  hsa00051+5213  
Galactose metabolism  hsa00052+5213  
Glycolysis / Gluconeogenesis  hsa00010+5213  
Metabolic pathways  hsa01100+5213  
Pentose phosphate pathway  hsa00030+5213  
According to Reactome, this protein belongs to the following pathway:
Glycolysis  REACT_1383  
 
More information is available from:
Note 
In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.  
1
  • UniProtKB
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P08237
Other
GeneWiki: PFKM
GenomeRNAi: 5213
PRO: PR:P08237