ASNS - Asparagine synthetase [glutamine-hydrolyzing] - human protein (Function)
 
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Protein
Gene
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ASNS »  Asparagine synthetase [glutamine-hydrolyzing]   [ EC 6.3.5.4 ]
 
Protein also known as:  Glutamine-dependent asparagine synthetase.
Gene name:  ASNS
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 59 3
GENE REF ISO

Function

 show evidences
GO molecular function 
Asparagine synthase (glutamine-hydrolyzing) activitydefinition[GO:0004066]  
5
  • UniProtKB
  • MGI
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Cofactor bindingdefinition[GO:0048037] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
GO biological process 
Asparagine biosynthetic processdefinition[GO:0006529]  
2
  • MGI
  • UniProtKB
Cellular response to glucose starvationdefinition[GO:0042149]  
1
  • UniProtKB
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
1
  • Ortholog Compara
Glutamine metabolic processdefinition[GO:0006541]  
1
  • UniProtKB KW
L-asparagine biosynthetic processdefinition[GO:0070981]  
1
  • UniPathway
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Positive regulation of mitotic cell cycledefinition[GO:0045931]  
1
  • UniProtKB
Response to amino aciddefinition[GO:0043200] silver  
1
  • Ortholog Compara
Response to follicle-stimulating hormonedefinition[GO:0032354] silver  
1
  • Ortholog Compara
Response to light stimulusdefinition[GO:0009416] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Response to methotrexatedefinition[GO:0031427] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.5.4: ATP + L-aspartate + L-glutamine + H(2)O AMP + diphosphate + L-asparagine + L-glutamate.  
2
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+440  
Metabolic pathways  hsa01100+440  
Nitrogen metabolism  hsa00910+440  
According to Reactome, this protein belongs to the following pathways:
Amino acid synthesis and interconversion (transamination)  REACT_238  
ATF4 activates genes  REACT_18355  
 

Keywords

Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Asparagine biosynthesis  definition   [KW-0061]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 440
PRO: PR:P08243